Acid-phosphatase activity in human neoplasms

Reiner, Leopold; Rutenburg, Alexander M.; Seligman, Arnold M.

doi:10.1002/1097-0142(195705/06)10:3<563::aid-cncr2820100321>3.0.co;2-i

Cited by 47 publications

(5 citation statements)

References 6 publications

(1 reference statement)

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“…Acid phosphatase from the human prostate can be demonstrated in the blood with immunological techniques [29] . Histochemically acid phosphatase could sometimes be demonstrated in the stroma adjacent to the acini [30,31].…”

Section: Exogenousmentioning

confidence: 99%

Androgen and collagen as growth regulators of the rat ventral prostate

Müntzing

1980

The Prostate

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With the aim of studying a possible role of the fibromuscular stroma as growth regulator for the rat ventral prostate the weight, DNA content, and hydroxyproline content were analyzed in the ventral prostate of rats of varying age. Exogenous androgen increased the age-dependent weight and contents only in young and old rats. Orchiectomy reduced prostatic weight, DNA content, and hydroxyproline content although to different extent, and exogenous androgen restored the weight and contents. Exogenous estrogen to intact animals had effects similar to orchiectomy. Estrogen combined with androgen increased DNA content over that found in animals given androgen only, while weight and hydroxyproline content were not changed. It is concluded that the endogenous androgen determines the size of the prostate in young and old animals. Androgen also determines prostatic collagen content. The good correlation between prostatic DNA and hydroxyproline indicates a more or less fixed number of epithelial cells per amount of collagen. A hypothesis suggesting a crucial role for prostatic collagen in the growth-limiting mechanism in the prostate is presented.

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Section: Exogenousmentioning

confidence: 99%

Androgen and collagen as growth regulators of the rat ventral prostate

Müntzing

1980

The Prostate

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“…Histochemists were dissatisfied with the Gomori method and its modifications for acid phosphatase. Reiner, Rutenburg and Seligman (1957), in a review of acid phosphatase activity in human tumours, used an azocoupling method which they had developed in which biopsies were fixed in cold neutral 10% formalin for 24 hours and then frozen sections were cut on which the reaction was applied; they obtained a strong positive reaction in prostatic carcinoma and gastro-intestinal neoplasms and moderate reactions in neoplasms of the breast, thyroid and skin. They noted that fixation in acid formalin reduced the enzyme reaction but reported a case in which a lymph node, infiltrated with a poorly differentiated carcinoma, gave a strong positive reaction for acid phosphatase although the material had been fixed in non-buffered formalin for 2 days and surgical investigations confirmed that the primary growth was in the prostate.…”

Section: Commentmentioning

confidence: 99%

Bilateral Breast Metastases from Carcinoma of the Prostate

Scott¹,

Robb‐Smith²,

Burns³

1974

British Journal of Urology

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SUMMARY A case of bilateral breast metastases developing in a patient with carcinoma of the prostate while on oestrogen therapy is described. Differentiation between prostatic metastases and primary breast tumours under these circumstances is important as the treatment for each is different. Such differentiation may be difficult by conventional histological techniques, but histochemical analysis can resolve the problem, as was possible in this case.

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“…His method produced positive results in 9 out of 9 cases of proven metastastic prostatic carcinoma, but negative results in 25 other types of metastasis. Reiner and his group (64) utilized an azo‐dye histochemical technique to identify a mystifying axillary lesion as metastatic from a previously undiagnosed carcinoma of the prostate. In contrast, their results were neither specific or consistent, when studying 14 primary carcinomas of the female breast.…”

Section: Histochemical Techniquesmentioning

confidence: 99%

“…The effect of estrogen therapy as a carcinogenic agent is also a question of great importance. It seemed pertinent, therefore, to review the literature on the subject (1–75), and to add the following case report…”

mentioning

confidence: 99%