Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex

Gottfries, C. G.; Gottfries, I.; Johansson, Barbro; Olsson, Rolf; Persson, Torgny; Roos, B. E.; Sjöström, Rolf

doi:10.1016/0028-3908(71)90081-5

Cited by 158 publications

(34 citation statements)

References 19 publications

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“…In addition, the levels reached at older ages are similar to those reported in other studies [1,8,15]. Regard less of the origin, all metabolites measured in the present study showed a significant nega tive correlation to age.…”

Section: Discussionsupporting

confidence: 80%

“…In the newborn the main clearane is via the CSF to the choroid plexus. In the adult, the majority of metabolites exit directly from brain to blood probably across the blood-brain capil lary endothelial barrier [11,12], However, age-related changes have been reported for monoamine metabolites in adults where both HVA and 5-HIAA increase with age [4,8].…”

Section: Discussionmentioning

confidence: 99%

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Developmental Variations in CSF Monoamine Metabolites during Childhood

Hedner¹,

Lundell

Breese

et al. 1986

Neonatology

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Cerebrospinal (CSF) fluid content of the stable metabolites homovanillic acid, 3-methoxy-4-hydroxyphenyl glycol and 5-hydroxyindoleacetic acid were measured in 19 children without neurological disease known to alter CSF monoamine metabolites. The CSF levels of all three metabolites were found to be up 6 times higher in early infancy compared to the values during adolescence. The levels decreased in a logarithmic fashion, and adult values (approx. 25–50 ng/ml) were reached at 3–5 years of age. Two different interpretations of the findings are discussed: (1) a higher release or turnover of central serotonin and catecholamine metabolites during early postnatal age, or (2) lower clearance of the stable acid metabolites from CSF during infancy due to relatively immature active transport mechanisms.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Developmental Variations in CSF Monoamine Metabolites during Childhood

Hedner¹,

Lundell

Breese

et al. 1986

Neonatology

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“…1973], Present biochemical results show absence of sex-related difference in mean u-HVA excretion. The same results were found for HVA assayed in the plasma [Bowers et al, 1983] and at CSF level [Bowers and Gerbode, 1968;Gottfries et al. 1971], Our study underlined sex-related differences when relations between Aug/Red and dopaminergic metabo lism were considered.…”

Section: Discussionsupporting

confidence: 70%

Frontal Auditory-Evoked Potential Augmenting-Reducing and Urinary Homovanillic Acid

Bruneau¹,

Barthélémy²,

Jouve³

et al. 1986

Neuropsychobiology

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Relationships between augmenting-reducing (Aug/Red) in auditory modality and dopaminergic metabolism were investigated in young adults with respect to sex. The slope values of evoked potential amplitude changes with increasing intensities were used to evaluate Aug/Red both at Cz and Fz for each of the five components: PI, Nl, P2, P1N1, N1P2. The greatest slopes (Aug) were found in females. Individual differences in dopaminergic metabolism were estimated by assaying free and conjugated forms of homovanillic acid (HVA) in urines. HVA excretion rates were significantly more variable in males than in females. Relationships between Aug/Red and HVA levels were only found in males. The lower the Aug/Red slopes recorded at Fz site for the Nl component (weak augmenter or reducer responses), the higher the urinary HVA level and particularly the conjugated forms of HVA. These results are of interest for further applications in psychopathology.

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“…Age and height were used as covariates in these analyses because these factors have been reported to influence CSF monoamine metabolite levels (Bowers and Ger bode 1968;Gottfries et al 1971;Wode-Helgodt and Sed vall 1978;Stanley et al 1985). In addition, it has been reported that the season of the year (i.e., summer, ,",,-in ter, spring, or fall) can influence CSF monoanune metabolite levels (Brewerton et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

McCann¹,

Ridenour

Shaham

et al. 1994

Neuropsychopharmacol

305

174

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(±)3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"), an increasingly popular recreational drug, is known to damage brain serotonin 5-hydroxytryptamine (5-HT) neurons in experimental animals. Whether MDMA is neurotoxic in humans has not been established. Thirty MDMA users and 28 controls were admitted to a controlled inpatient setting for measurement of biologic and behavioral indexes of central 5-HT function. Outcome measures obtained after at least 2 weeks of drug abstinence included concentrations of monoamine metabolites in cerebrospinal fluid (CSF), prolactin responses to L-tryptophan, nociceptive responses to ischemic pain, and personality characteristics in which 5-HT has been implicated (i.e., impulsivity and aggression). Subjects with a history of MDMA exposure had lower levels of CSF 5-hydroxyindoleacetic acid (the

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Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex

Cited by 158 publications

References 19 publications

Developmental Variations in CSF Monoamine Metabolites during Childhood

Developmental Variations in CSF Monoamine Metabolites during Childhood

Frontal Auditory-Evoked Potential Augmenting-Reducing and Urinary Homovanillic Acid

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

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