Acid fuchsin-interleaved Mg–Al-layered double hydroxide for the formation of an organic–inorganic hybrid nanocomposite

Hussein, Mohd Zobir; Yahaya, Asmah Hj; Shamsul, Mohd Tamrin Bahri; Salleh, Hairi Mohd; Yap, Taufiq Yun Hin; Kiu, Jacqueline

doi:10.1016/s0167-577x(03)00480-4

Cited by 28 publications

(13 citation statements)

References 15 publications

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“…32 delivery platform. [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] Many important biomolecular agents which are negatively charged anions (e.g. glycerol, organic acids, porphyrins, nucleotides, ATP, vitamins, DNA and drugs), with varying shape and size, have been intercalated inside the (Mg,Al) LDH structure using a range of methods.…”

Section: Methodsmentioning

confidence: 99%

“…bisphosphonate, camptothecin, methotrexate) into LDHN, controlled (passive) release studies, and in vitro bioassays were documented. [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] It is believed that the uptake of LDHN by a cell and release of its biomolecular agent occurs by endocytosis and lysosomal degradation respectively. 40 39 Following their successful intercalation of DNA molecules, they also recognised the potential of LDHN as a passive delivery platform for non-viral gene therapy.…”

Section: Methodsmentioning

confidence: 99%

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Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation

Dey¹,

Sistiabudi²

2007

Materials Research Innovations

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Since 2001, intercalated or biohybridised ceramics based on layered double (M 2z ,M 3z ) hydroxide nanoparticles (LDHN) have been evaluated as a passive vector for drug and non-viral gene delivery. This paper identifies the attributes of LDHN as a passive delivery platform, judiciously selects and discusses issues in synthesis of physiologically relevant compositions, and demonstrates surface activation of (Mg 2z ,Al 3z ) LDHN; the latter a critical first step in the surface functionalisation process for active targeting. After a description of the layered double hydroxide (LDH) structure and unique attributes of LDHN as a passive platform, the advantages and issues of a robust LDHN surface functionalisation process for active targeting are identified. Next, the judicious selection of physiological relevant (Mg 2z ,Fe 3z ) and (Zn 2z ,Fe 3z ) LDH compositions is made, and their synthesis by precipitation and potential difficulties are discussed. Finally, the surface activation of (Mg 2z ,Al 3z ) LDHN is demonstrated by a bimolecular, nucleophilic substitution type reaction using acryloyl chloride.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation

Dey¹,

Sistiabudi²

2007

Materials Research Innovations

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“…Elemental analysis shows the molar ratio of Zn to Al in clorrop-LDH 2.9 compared to 3.0 for the value initially prepared for the mother liquor. This indicates that the Zn to Al molar ratio in the resulting synthesized materials was adjusted accordingly for the formation of the positively charged inorganic layers to compensate the negatively charged intercalated anion so that the resulting materials cloprop-LDH is neutrally charged [17].…”

Section: Ftirmentioning

confidence: 99%

Synthesis and controlled release of cloprop herbicides from cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposites

Hashim¹,

Hussein²,

Isa³

et al. 2014

OJIC

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Two phenoxyherbicide nanocomposites, namely cloprop-layered double hydroxide and cloprop-zinclayered hydroxide nanocomposites, have been synthesized by using co-precipitation and direct reaction method. PXRD pattern showed an expansion of interlayer spacing with the value of 21.0 Å and 22.7 Å for cloprop-layered double hydroxide and cloprop-zinclayered hydroxide nanocomposite, respectively. It is evident from FTIR and elemental analyses that both nanocomposites were successfully intercalated between the interlayers of layered metal hydroxide. Controlled release of cloprop anion from interlayer of nanocomposites for both cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposite into phosphate solution was rapid initially and slow thereafter. The percentage of accumulated release of cloprop anion from cloprop-zinc-layered hydroxide nanocomposite was slightly higher than that from cloprop-layered double hydroxide nanocomposite. Kinetic behavior of cloprop release was governed by pseudo-second-order for cloprop-layered double hydroxide nanocomposite while parabolic diffusion for cloprop-zinc-layered hydroxide nanocomposite. Results from this study highlight the potential of both nanocomposites as capsulated material for controlled release of cloprop phenoxyherbicides anion.

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“…Research on the potential applications of LDHs has been attracting considerable attention over the last decade [15][16][17] ) generates positive charges in-between the hydroxide layers, which will be compensated by the counter anion (A m-) and water molecules. LDHs are very versatile inorganic compound as they can be incorporated with various types of anion into their interlayer region.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study

Ajat¹,

Yusoff²,

Hussein³

2008

CNANO

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A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 g/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides.

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Acid fuchsin-interleaved Mg–Al-layered double hydroxide for the formation of an organic–inorganic hybrid nanocomposite

Cited by 28 publications

References 15 publications

Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation

Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation

Synthesis and controlled release of cloprop herbicides from cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposites

Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study

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