Acid-Base Status of Seriously Wounded Combat Casualties

Collins, John A.; Simmons, Richard L.; James, Paul M.; Bredenberg, Carl E.; Anderson, Robert; Heisterkamp, Charles A.

doi:10.1097/00000658-197101000-00002

Cited by 33 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, FFP significantly blunted the mixed respiratory and metabolic acidosis, which also resulted in a less severe hyperkalemia. It has long been recognized that the abundance of negatively charged proteins in plasma, as well as the sodium citrate (34) used to collect donor blood (as was used in this study), makes plasma an excellent buffer for acidosis (35). This is in contrast to NS, which is known to induce a non-anion gap metabolic acidosis.…”

Section: Discussionmentioning

confidence: 99%

Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

Chang

Holcomb

Johansson

et al. 2018

Shock

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

Chang

Holcomb

Johansson

et al. 2018

Shock

View full text Add to dashboard Cite

show abstract

“…The existence of a distinct coagulopathic process associated with severe trauma was first recognized during the Vietnam War 1‐3 . In‐depth investigation of this phenomenon, however, was slowed by its initial characterization as a secondary effect of hypoxemia, acidosis, and the overuse of crystalloid fluid resuscitation 4‐6 or with organ‐specific brain, orthopedic, and obstetric trauma and burns 7‐11 . More recently, the coagulopathy of trauma, as a syndrome of nonsurgical bleeding from mucosal lesions, serosal surfaces, and wound and vascular access sites, has been characterized as commonly associated with any serious physical traumatic injury and often accompanied by hypothermia, acidosis, and hemodilution and occasionally with consumption and fibrinolysis 12 .…”

mentioning

confidence: 99%

The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center

et al. 2008

View full text Add to dashboard Cite

BACKGROUND:Several groups have reported that a fraction of severely injured patients have abnormal coagulation tests at presentation to trauma centers, even in the absence of significant crystalloid resuscitation. These patients have high mortality, but their prevalence in trauma populations is not clear from the reports. STUDY DESIGN AND METHODS:Records of all patients admitted to a large urban trauma center during 2000 through 2006 were searched for early measures of common coagulation tests and in-hospital mortality. RESULTS: Abnormal coagulation tests were increasingly frequent with increasing injury severity, ranging from 5 to 43 percent for the prothrombin time as the injury severity scores (ISSs) increased from 5 to more than 45 and 4 to 18 percent for platelet counts of less than 150 ¥ 10 9 per L. Abnormal coagulation tests were associated with excess mortality even below conventional transfusion triggers and this was especially true for the partial thromboplastin time. CONCLUSIONS: Abnormal coagulation tests are common in severely injured patients. Even in the moderately injured, they are associated with higher mortality.

show abstract

“…Administration of large quantities of acidic blood, together with the metabolic acidosis common in these patients before resuscitation, would lead one to expect worsening acidosis as the outcome of massive transfusion. However, patients are more likely to exhibit metabolic alkalosis at the end of the transfusion episode, 120,121 partly because of improved tissue perfusion and the metabolism of citrate and lactate to bicarbonate. Patients in renal failure may be unable to handle the bicarbonate load and require dialysis.…”

Section: Massive Transfusionmentioning

confidence: 99%

Delayed gastric emptying in critical illness: Is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?*

Samis¹

2008

Critical Care Medicine

View full text Add to dashboard Cite

Most patients admitted to an intensive care unit (ICU) require the administration of one or more blood components during their stay. Such patients exhibit great diversity in conditions necessitating care in the ICU, age, underlying medical problems, and integrity of physiologic compensatory mechanisms. All these patients, however, share the need for optimized oxygen-carrying capacity and tissue perfusion. Ongoing blood loss resulting from injuries, surgical wounds, invasive monitoring equipment, and blood sampling requirements, coupled with inadequate marrow function and, in some, red cell destruction,

show abstract

Acid-Base Status of Seriously Wounded Combat Casualties

Cited by 33 publications

References 33 publications

Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center

Delayed gastric emptying in critical illness: Is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?*

Contact Info

Product

Resources

About