Acid-Base Changes of Mature and Premature Neonates following Exchange Transfusion

Hervei, S; Malik, Teréz; Rötfalusy, Mária

doi:10.1159/000240882

Cited by 3 publications

(1 citation statement)

References 12 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20-7.30) for exchange transfusions is superior to acidcitrate-dextrose (ACD) blood (pH about 6.7), CPD blood (pH about 6.9), and heparinized blood. ACD blood even induces a metabolic acidosis (23)(24)(25)(26), which will in itself increase the risk of bilirubin encephalopathy. Citrate was not found to affect the bilirubin-albumin binding.…”

Section: Effecr Of Exchange Transfiasion 647mentioning

confidence: 99%

Effect of Exchange Transfusion on Serum Reserve Albumin for Binding of Bilirubin and Index of Serum Bilirubin Toxicity

Ebbesen¹

1981

Acta Paediatrica

View full text Add to dashboard Cite

Seventeen newborn infants, who received their first exchange transfusion due to hyperbilirubinaemia and/or rhesus haemolytic disease, were studied. The exchange transfusions were performed with fresh, citrated blood. During the exchange transfusion a marked increase in the serum reserve albumin concentration for binding of bilirubin measured by the [14C]-MADDS method was observed, followed by a smaller decrease after the transfusion. Plasma pH increased both during and after the exchange transfusion. During the exchange transfusion a drastic fall in index of serum bilirubin toxicity was observed, followed by a smaller increase after the transfusion. Citrate was not found to interfere in the binding of bilirubin to albumin. The results are in agreement with the clinical finding that an exchange transfusion performed with fresh, citrated blood effectively reduced the risk of bilirubin encephalopathy. The ratio in serum of binding albumin, i.e. bilirubin plus reserve albumin, to total albumin failed to be increased by the exchange transfusion, and a decrease occurred after the transfusion. These findings indicate the presence in infant serum of non-binding albumin. Donor albumin with intact binding potential is partly transformed into the non-binding variety in the course of one hour after the transfusion. In the most severely rhesus sensitized infant a drastic decline of the serum albumin binding capacity was seen during the first day of life.

show abstract

Section: Effecr Of Exchange Transfiasion 647mentioning

confidence: 99%