Acid-Base Changes in Cerebrospinal Fluid of Infants with Metabolic Acidosis

Albert, Morris S.; Rahill, W. Joseph; Vega, Luis Alberto; Winters, Robert W.

doi:10.1056/nejm196603312741306

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…CSF bicarbonate is significantly higher than arterial bicarbonate (0-01>P>0 002) which is the reverse of the normal relationship in adult men (Bradly and Semple, 1962). These findings are consistent with mild systemic metabolic acidosis (Albert et al, 1966). Lactate and pyruvate.…”

Section: Febrile Convulsionssupporting

confidence: 82%

Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after short (less than 30 minutes) first febrile convulsions in children.

Simpson¹,

Habel²,

George³

1977

Archives of Disease in Childhood

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SUMMARY Twenty-nine infants and children with short (<30 minutes) first febrile convulsions were studied between 3 and 22 hours after convulsive episodes. Arterial and CSF acid-base variables, lactate and pyruvate concentrations, and lactate/pyruvate ratios were measured. Biochemical signs of cerebral hypoxia were found in only 2 patients, one of whom had short, repeated convulsions. Our findings indicate that hypoxic damage is unlikely to result from a short-duration febrile convulsion.Febrile convulsions affect some 6 % of young children mainly between the ages of 6 months and 4 years. The long-term prognosis for such patients is usually good, though a small number, at most 5-10%, ultimately develop chronic epilepsy (see review by Lennox-Buchthal, 1973). Moreover, when

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Section: Febrile Convulsionssupporting

confidence: 82%

Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after short (less than 30 minutes) first febrile convulsions in children.

Simpson¹,

Habel²,

George³

1977

Archives of Disease in Childhood

View full text Add to dashboard Cite

show abstract

“…Lactate and pyrurate in CSF Nornial neonnres (Group I): Table 4 presents the mean values, the standard deviations and the ranges of the CSF lactate and pyruvate concentrations as well as of the CSF lactateipyruvate ratios. In the control group of 19 neonates (1). without perinatal asphyxia (Group I) the means and standard deviations were for lactate 1.601 0.322 mMol/l> for pyruvate 0.098 k0.017 mMol/l, and for lactate]pyrucate ratio 16.5 f0.8.…”

Section: Acid-base Variables (mentioning

confidence: 96%

“…In the following presentation the results in group The clinical criteria of perinatal asphyxia in this study were: Fetal heart rate dropping below 20 beats per 15 sec (intrauterine asphyxia) and/or Apgar score below 6 points at 10 min after delivery (including heart rate Case weight nal age score below 100 beats per minute) and/or cyanotic attacks or No. (9) (weeks) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) 10-10 10-10 10-10 8-10 8-10 10-10 9-1 0 10-10 8-10 10-10 9-10 10-10 10-10 10-10 10-10 9-10 9-10 10-10 10-10…”

Section: Neonates With Clinical Signs Of Asphyxia (Croup Iz)mentioning

confidence: 99%