Acid and Pepsin Secretion in Chronic Chagas’ Disease Patients in Response to Graded Doses of Pentagastrin and Pentagastrin plus Bethanecol

Padovan, W.; Godoy, Renato Alves de; Meneghelli, U. G.; Dantas, Roberto Oliveira; Oliveira, Ricardo Brandt de; Troncon, L.E.A.

doi:10.1159/000198709

Cited by 23 publications

(19 citation statements)

References 4 publications

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“…This fi nding indicates that patients with the digestive form are not at high risk for H. pylori infection, although these patients have hypochlorhydria 7,8,10 , which a condition that can favor gastric colonization by H. pylori 32,33 .…”

Section: Discussionmentioning

confidence: 90%

“…Previously, the chronic gastritis commonly observed in chagasic patients primarily with the digestive form of Chagas disease was attributed to biliary duodenal-gastric refl ux, as well as gastric hypomotility and hypochlorhydria caused by enteric nervous system injury due to chronic T. cruzi infection [7][8][9][10][11] . However, these studies were performed before the recognition that infection with the bacterium Helicobacter pylori is the main cause of chronic gastritis throughout the world and plays an important role in peptic ulcers, gastric carcinoma and mucosaassociated lymphoid tissue (MALT) lymphoma 12 …”

Section: Methodsmentioning

confidence: 99%

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Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Fonseca

Etchebehere

Queiroz

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Fonseca

Etchebehere

Queiroz

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…There is decreased gastric secretion (190) and reduced acid and pepsin output in response to pentagastrin; this may be corrected by bethanechol (189). Approximately one-third of patients with gastrointestinal organomegaly and one-third of patients with cardiomyopathy are achlorhydric (86).…”

Section: Stomachmentioning

confidence: 99%

Chagas' disease

et al. 1992

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Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS.

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“…It is well recognised that reduced secretion of gastric acid is a predisposing factor to infection with various enteric pathogenic bacteria [16][17][18][19] as well as some parasitic infections including strongyloidiasis [20], Chagas' disease [21] and schistosomiasis [22]. Such infections are a major cause of morbidity and mortality.…”

Section: Consequences Of Achlorhydriamentioning

confidence: 99%