2000
DOI: 10.1046/j.1523-1755.2000.00282.x
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Acid and mineral balances and bone in familial proximal renal tubular acidosis

Abstract: The results indicate that this chronic metabolic acidosis reduces growth, including that of bone. We speculate, without direct supporting evidence, that bone stores of HCO3-/CO3= are reduced, as has been observed in patients with the metabolic acidosis of chronic renal failure and in experimental metabolic acidosis in animals.

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Cited by 70 publications
(47 citation statements)
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“…Net fixed acid production was normal and appropriate for their body weights, averaging 0.9 and 10.2 mEq/kg per d. Acid balance was near zero, at 1.9 Ϯ 2.3 and Ϫ2.2 Ϯ 2.2 mEq/d. Urine calcium excretion was normal (29). Associated clinical findings were limited growth retardation and reduced bone densities.…”
Section: Autosomal Dominant Prtamentioning
confidence: 97%
“…Net fixed acid production was normal and appropriate for their body weights, averaging 0.9 and 10.2 mEq/kg per d. Acid balance was near zero, at 1.9 Ϯ 2.3 and Ϫ2.2 Ϯ 2.2 mEq/d. Urine calcium excretion was normal (29). Associated clinical findings were limited growth retardation and reduced bone densities.…”
Section: Autosomal Dominant Prtamentioning
confidence: 97%
“…Decreased proximal tubule bicarbonate absorption causes proximal renal tubular acidosis (1)(2)(3)(4). Familial autosomal recessive proximal renal tubular acidosis results from mutations in the electrogenic sodium bicarbonate cotransporter NBCe1-A encoded by the SLC4A4 gene (5,6).…”
Section: T442cmentioning
confidence: 99%
“…Patients with isolated familial proximal RTA have been observed to exhibit normal rates of both acid production and net acid excretion and thus are in acid balance. Moreover, they also exhibit normal rates of urinary and fecal Ca 2ϩ excretion relative to their Ca 2ϩ intakes and are in Ca 2ϩ balance (32). Thus it appears that both positive acid balances and increased Ca 2ϩ excretion rates are necessary for the development of negative Ca 2ϩ balances in the presence of metabolic acidosis.…”
Section: Evaluation Of the Acidosis Of Chronic Azotemic Kidney Diseasmentioning
confidence: 99%