2011
DOI: 10.1021/bm200876x
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Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

Abstract: Endosomal pH-activatable doxorubicin (DOX) prodrug nanogels were designed, prepared, and investigated for triggered intracellular drug release in cancer cells. DOX prodrugs with drug grafting contents of 3.9, 5.7, and 11.7 wt % (denoted as prodrugs 1, 2, and 3, respectively) were conveniently obtained by sequential treatment of poly(ethylene glycol)-b-poly(2-hydroxyethyl methacrylate-co-ethyl glycinate methacrylamide) (PEG-b-P(HEMA-co-EGMA)) copolymers with hydrazine and doxorubicin hydrochloride. Notably, pro… Show more

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Cited by 129 publications
(77 citation statements)
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“…Examples of agents sensitive to such pH changes include polymers [1517], pH sensitive nanogels [18, 19], as well as proteins critical to pathogen infection such as the hemagglutinin glycoprotein from influenza [20], listeriolysin [21], melittin [22], and many other viral proteins. These and many others have been creatively employed in a host of drug delivery strategies over the past several decades, with varying success.…”
Section: Cellular Internalization Pathwaysmentioning
confidence: 99%
“…Examples of agents sensitive to such pH changes include polymers [1517], pH sensitive nanogels [18, 19], as well as proteins critical to pathogen infection such as the hemagglutinin glycoprotein from influenza [20], listeriolysin [21], melittin [22], and many other viral proteins. These and many others have been creatively employed in a host of drug delivery strategies over the past several decades, with varying success.…”
Section: Cellular Internalization Pathwaysmentioning
confidence: 99%
“…Polymer drug conjugates prepared from biocompatible, water soluble polymers have received tremendous interest for targeted cancer therapy [12]. These conjugates improve the solubility of hydrophobic drugs and protect them from degradation leading to increased bioavailability [13].…”
Section: Page 4 Of 25mentioning
confidence: 99%
“…Upto-date, various pH-sensitive polymeric prodrugs have been developed for loading and triggered release of poorly water-soluble anticancer drugs including DOX and PTX [27][28][29][30][31][32][33]. For instance, Zhan et al reported endosomal pHactivatable doxorubicin (DOX) prodrug nanogels by conjugating DOX via an hydrazone bond showed pH-dependent PTX release and better cytotoxic effects to RAW 264.7 and MCF-7 tumor cells [34].…”
Section: Introductionmentioning
confidence: 99%