Acicular, but not globular, titanium dioxide nanoparticles stimulate keratinocytes to produce cytokines independently of inflammasome

Hiroike, Mizuho; Sakabe, Jun‐ichi; Miwa, Koichi; Hirakawa, Satoshi; Inoh, Akinori; Tokura, Y.

doi:10.1016/j.jdermsci.2012.11.549

Cited by 2 publications

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“…Dose-dependent TNFα release has been noted following keratinocyte exposure to AgNP, QD, and ZnO NP, indicating high doses may promote LC maturation and dermal sensitization (Samberg et al 2010; Romoser et al 2011; Jeong et al 2013). IL-18 and IL-1β (cytokines critical for LC activity) have also been shown to be increased by QD, SiO 2 NP, TiO 2 NP, and AgNP (Ryman-Rasmussen et al 2007; Samberg et al 2010; Yazdi et al 2010; Romoser et al 2011; Hiroike et al 2013; Zhang and Monteiro-Riviere 2019).…”

Section: Metal Nanomaterials and Dermal Hypersensitivitymentioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/ exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

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Section: Metal Nanomaterials and Dermal Hypersensitivitymentioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Dose-dependent TNF-α release has been observed following keratinocyte exposure to AgNP, QD, and ZnONP, indicating that high doses may promote LC maturation and dermal sensitization (679,684,685). IL-18 and IL-1β are also cytokines critical for LC activity that have been shown to be increased following exposure to QD, SiO2NP, TiO2NP, and AgNP (679,684,(686)(687)(688)(689).…”

Section: Skin Sensitization Studiesmentioning

confidence: 99%

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

Roach¹

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The recent surge in incorporation of engineered metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings has raised concerns over their potential to induce material size-specific toxicological effects. Although metal nanomaterials have been shown to induce greater degrees of lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy.Overall, more scientific knowledge exists regarding the potential for metal-containing nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Despite the existence of such knowledge, specific correlations between metal nanomaterial physico-chemical properties and their allergic effects have yet to be consistently demonstrated. As the number of emerging nanomaterials continues to increase, the delineation of these relationships has the potential to advance risk assessment efforts by helping to identify specific agents that may present an elevated risk for allergic effects.Two sets of studies were designed to begin addressing some of the knowledge gaps associated with the immunotoxic potential of metal nanomaterials in the context of allergic disease. The hypothesis of these studies was that nanomaterials comprised of metal constituents with known immunomodulatory potential augment, induce, and elicit allergic disease more readily than larger forms of the materials. Moreover, the nature of the immune responses caused by exposure to these metal nanomaterials, as well as the magnitude of the effects, correlates best with the parameter of dose surface area.The first set of studies incorporated NiO particles with different physico-chemical properties into an in vivo time course study and OVA asthma model. Results from the time course study demonstrated that the smaller NiO particles caused more pronounced pulmonary injury and inflammation, a discrepancy that could be mitigated by normalizing the administered particle dose to the surface area of the larger material. In the OVA model, augmentation of the allergic response was largely conserved with respect to NiO surface area, wherein larger doses caused polarization of pulmonary immune reposes towards a Th1/17-dominant state and smaller doses induced Th2-skewed responses. Despite this association, several immune markers, including total IgE production, BAL eosinophil number, and Penh response correlated better with other metrics, such as particle size.The second set of studies employed Au particles and nanoparticles to assess size-specific differences in allergenic potential. Neither particle was associated with potential for skin...

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Acicular, but not globular, titanium dioxide nanoparticles stimulate keratinocytes to produce cytokines independently of inflammasome

Cited by 2 publications

References 0 publications

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

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