Aciclovir Treatment in Experimental Herpetic Keratitis in Rabbits

Oosterhuis, J. A.; Versteeg, J.; Kruit, P. J.; Postma, Bent

doi:10.1159/000265059

Cited by 14 publications

(7 citation statements)

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“…Both eyes of each rabbit were inoculated without scarification. In order to enhance the infection and to obtain a constant degree of herpetic keratitis reaction, one 5 % cocaine hydrochloride drop was, at first, instillated in the lower conjunctival cul de sac, as described by Oosterhuis (6,7). Then, each eye received two drops of a suspension of herpes simplex hominis virus type 1 containing 106 TCID per ml.…”

Section: Infection Of Rabbit Eyesmentioning

confidence: 99%

Effect of Saponins fromAnagallis arvensison Experimental Herpes Simplex Keratitis in Rabbits

Amoros¹,

Fauconnier²,

Girre³

1988

Planta Med

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Section: Infection Of Rabbit Eyesmentioning

confidence: 99%

Effect of Saponins fromAnagallis arvensison Experimental Herpes Simplex Keratitis in Rabbits

Amoros¹,

Fauconnier²,

Girre³

1988

Planta Med

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“…In all cases herpetic corneal lesions healed in 2 days (Oosterhuis et al, 1980). In all cases herpetic corneal lesions healed in 2 days (Oosterhuis et al, 1980).…”

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confidence: 75%

Aciclovir and Trifluorothymidine in herpetic keratitis preliminary report of a multicentered trial

Lau¹,

Oosterhuis²,

Versteeg³

et al. 1981

Doc Ophthalmol

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The efficacy of Aciclovir and Trifluorothymidine (TFT) treatment was tested in a double blind trial of thirty-eight patients with dendritic keratitis. All twenty patients treated with Aciclovir healed within 10 days with an average healing time of 5.0 days. Two of the eighteen patients treated with TFT failed to heal within 22 days, the others healed within ten days, the average healing was 6.6 days. Punctate keratopathy was seen in 70% of both groups. Intense conjunctival hyperaemia developed in two TFT patients.

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“…patients agree with the favourable results of ignificant. Nor experiments in rabbits.1 [7][8][9][10][11] Other results of clinical between the trials with 3% ACV ointment in dendritic or geoitment and the graphic herpetic keratitis are also favourable and vas started. agree with our results.`-`' The average healing time in our series of ACV-treated patients was 6-3 days, which is longer than the 4-4 days in the series of Collum et al 3 In our preliminary study 20 ACV-treated patients had healed within 10 days,6 but in the present series 4 out of the 31 eyes failed to heal.…”

Section: Resultsmentioning

confidence: 99%

Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.

Lau¹,

Oosterhuis²,

Versteeg³

et al. 1982

British Journal of Ophthalmology

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SUMMARY A randomised double blind study was performed on 59 patients with dendritic herpetic keratitis treated with 3% acyclovir or 2% trifluorothymidine ointment. Both drugs were highly effective and gave 87% (ACV) and 82% (T1F') success rates. Punctate keratopathy occurred in 70% of the patients, but serious side effects were not observed.Since the introduction of idoxuridine (IDU) as an antiviral drug for the treatment of herpetic keratitis more potent drugs have become available. Arabinoside adenine and trifluorothymidine (TFT) are both effective and relatively nontoxic alternatives widely used in the management of herpetic disease.' Acyclovir (ACV) (9-(2-hydroxyethoxymethyl) guanine)2 and (E)-5(2-bromovinyl)-2' deoxyuridine),3 recently developed antiviral compounds with potent inhibitory activity against herpes simplex DNA polymerase, do not inhibit normal human cell DNA polymerase.For a comparative study we selected 2 of the antiviral drugs which we considered to be the most potent -acyclovir and trifluorothymidine.45 Material and methods Fifty-nine patients with dendritic keratitis were studied. Patients with stromal keratitis and patients treated by antiviral agents and/or corticosteroids prior to referral were excluded. In a randomised double-blind study we used 3% acyclovir and 2% trifluorothymidine ointment, both specially prepared for this trial and packed in identical tubes obtained through the kind co-operation of Wellcome Laboratories (England) and Dr Gerhard Mann, Hamburg (FRG), respectively. The ointment was prescribed 5 times daily. Cycloplegics were given for intraocular irritation.After healing was complete the treatment was continued for 7 days. It was discontinued if after 7 days no therapeutic effect was observed or if after 14 days the keratitis had not healed completely.

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Aciclovir Treatment in Experimental Herpetic Keratitis in Rabbits

Abstract: In experimental herpetic keratitis in rabbits, aciclovir proved to have a high antiviral activity, superior to that of idoxuridine. Viral encephalitis was partly prevented by local treatment and fully by systemic treatment with aciclovir.

Cited by 14 publications

References 1 publication

Effect of Saponins fromAnagallis arvensison Experimental Herpes Simplex Keratitis in Rabbits

Effect of Saponins fromAnagallis arvensison Experimental Herpes Simplex Keratitis in Rabbits

Aciclovir and Trifluorothymidine in herpetic keratitis preliminary report of a multicentered trial

Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.

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