Achyrofuran is an antibacterial agent capable of killing methicillin-resistant vancomycin-intermediate Staphylococcus aureus in the nanomolar range

Casero, Carina Noelia; Estévez‐Braun, Ana; Ravelo, Ángel G.; Demo, Mirta Susana; Méndez-Álvarez, Sebastián; Machín, Félix

doi:10.1016/j.phymed.2012.11.003

Cited by 23 publications

(17 citation statements)

References 18 publications

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“…Many bacterial pathogens associated with epidemics of gastrointestinal tract disorders in humans, such as Escherichia coli , Salmonella spp., and Staphylococcus aureus , have evolved multidrug-resistant forms subsequent to antibiotic use [ 1 ]. The extensive use of antibiotics over the last decade has led to the emergence of bacterial resistance and the dissemination of resistant genes among pathogenic microorganisms [ 2 ]. In recent years, several associations between common chronic human disorders and an altered composition and function of the gut microbiome have been reported [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation

Moresco

Silveira

Zeidán-Chuliá

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Three Achyrocline satureioides (AS) inflorescences extracts were characterized: (i) a freeze-dried extract prepared from the aqueous extractive solution and (ii) a freeze-dried and (iii) a spray-dried extract prepared from hydroethanol extractive solution (80% ethanol). The chemical profile, antioxidant potential, and antimicrobial activity against intestinal pathogenic bacteria of AS extracts were evaluated. In vitro antioxidant activity was determined by the total reactive antioxidant potential (TRAP) assay. In vivo analysis and characterization of intestinal microbiota were performed in male Wistar rats (saline versus treated animals with AS dried extracts) by high-throughput sequencing analysis: metabarcoding. Antimicrobial activity was tested in vitro by the disc diffusion tests. Moisture content of the extracts ranged from 10 to 15% and 5.7 to 17 mg kg−1 of fluorine. AS exhibited antioxidant activity, especially in its freeze-dried form which also exhibited a wide spectrum of antimicrobial activity against intestinal pathogenic bacteria greater than those observed by the antibiotic, amoxicillin, when tested against Bacillus cereus and Staphylococcus aureus. Antioxidant and antimicrobial activities of AS extracts seemed to be positively correlated with the present amount of flavonoids. These findings suggest a potential use of AS as a coadjuvant agent for treating bacterial-induced intestinal diseases with high rates of antibiotic resistance.

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Section: Introductionmentioning

confidence: 99%

Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation

Moresco

Silveira

Zeidán-Chuliá

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…One apparently feasible approach to the problem is to develop new antibacterial agents present in a high number of sources, such as plant-derived extracts and compounds (Michielin et al 2009). Currently, there are many other extracts and (or) compounds isolated from plants that have anti-MRSA activities (Zoraghi et al 2011;Casero et al 2013;Patel et al 2013). However, many of these agents are difficult to obtain or not very effective against MRSA clinical strains.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, methicillin-resistant Staphylococcus aureus (MRSA) has developed as the predominant pathogenic bacterium of hospital infections, leading to high morbidity and mortality (Andersson and Hughes 2010;Casero et al 2013). The ␤-lactam antibiotics have been the effective agents against staphylococcal infections prior to the emergence of MRSA, but resistance to antibiotics (including ␤-lactams) is increasing because of the uncontrolled use of antibiotics (Villegas-Estrada et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Emodin is identified as the active component of ether extracts from Rhizoma Polygoni Cuspidati, for anti-MRSA activity

Chen

Peng

et al. 2015

Can. J. Physiol. Pharmacol.

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This study investigated the anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity and chemical compositions of ether extracts from Rhizoma Polygoni Cuspidati (ET-RPC). Significant anti-MRSA activities of ET-RPC against MRSA252 and MRSA clinical strains were tested in in vitro antibacterial experiments, such as inhibition zone diameter test, minimal inhibitory concentration test, and dynamic bacterial growth assay. Subsequently, 7 major compounds of ET-RPC were purified and identified as polydatin, resveratrol-4-O-d-(6'-galloyl)-glucopyranoside, resveratrol, torachryson-8-O-glucoside, emodin-8-O-glucoside, 6-hydroxy-emodin, and emodin using liquid chromatography - electrospray ionization - tandem mass spectrometry. After investigation of anti-MRSA activities of the 7 major compounds, only emodin had significant anti-MRSA activity. Further, transmission electron microscopy was used to observe morphological changes in the cell wall of MRSA252, and the result revealed that emodin could damage the integrity of cell wall, leading to loss of intracellular components. In summary, our results showed ET-RPC could significantly inhibit bacterial growth of MRSA strains. Emodin was identified as the major compound with anti-MRSA activity; this activity was related to destruction of the integrity of the cell wall and cell membrane.

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“…For example, methyl angolensate, a compound isolated from the Indian plant Soymida febrifuga, has the same structural motifs as secochiliolide acid, and displayed antibacterial, antifungal and insect antifeedant properties (Samir et al, 2001;Chiruvella et al, 2007). Also, benzofurans, furanocoumarins, furoflavones, furanochalcones and furanoterpenes, all of which share with compound 1 a furan ring moiety, and can be isolated from terrestrial plants, have shown a broad range of biological activities such as antibacterial and antifungal properties (Sardari et al, 2000;DellaGreca et al, 2001;Waridel et al, 2003;Widelski et al, 2009;Alam and Lee, 2011;Kamal et al, 2011;Tran et al, 2012;Casero et al, 2013). In particular, imperatorin, a furanocoumarin, showed high inhibitory activity against larval settlement of Balanus albicostatus (Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effect of secochiliolide acid isolated from the Patagonian shrub Nardophyllum bryoides as active component in antifouling paints

Pérez

Garcia

Sánchez

et al. 2014

International Biodeterioration & Biodegradation

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Environmental concerns about the use of toxic antifoulants have led to an increased interest in the development of new alternatives. So far, most of the antifouling natural products have been obtained from marine organisms. However, some secondary metabolites from terrestrial plants could be promising antifoulant candidates. The antifouling performance of secochiliolide acid, the main component isolated from Nardophyllum bryoides ethanolic extract, was evaluated for inclusion in rosin-based coatings. Field testing was conducted during the summer months at Mar del Plata harbor, Argentina. The results indicated that secochiliolide acid-based paints completely inhibited the settlement of Bugula neritina colonies, Polydora sp., Hydroides elegans, Corophium sp. and solitary ascidians, and also reduced the attachment of some algae as Enteromorpha intestinalis and Ectocarpus sp. In addition, a lower density and diversity of microfouling species was registered. These results highlighted the importance of terrestrial plants as a sustainable source of potential environmentally friendly antifoulants.

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Achyrofuran is an antibacterial agent capable of killing methicillin-resistant vancomycin-intermediate Staphylococcus aureus in the nanomolar range

Cited by 23 publications

References 18 publications

Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation

Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation

Emodin is identified as the active component of ether extracts from Rhizoma Polygoni Cuspidati, for anti-MRSA activity

Effect of secochiliolide acid isolated from the Patagonian shrub Nardophyllum bryoides as active component in antifouling paints

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