Achyranthes bidentata polypeptides promotes migration of Schwann cells via NOX4/DUOX2-dependent ROS production in rats

Song, Honghua; Zhao, Hualong; Yang, Lingyan; Li, Lilan; Zhang, Tuanjie; Pan, Jiacheng; Meng, Yali; Shen, Weisen; Yuan, Ying

doi:10.1016/j.neulet.2018.12.023

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…To date, studies have explored the potential of 20 species of plants, three species of mushrooms, and four types of decoctions in promoting peripheral nerve regeneration ( Table 1 ). Notably, the neuroregenerative potential of Achyranthes bidentata [ 44 , 45 , 46 , 47 , 48 , 49 ], Astragalus membranaceus [ 52 , 53 , 54 , 55 ], Curcuma longa [ 60 , 61 , 62 , 63 , 64 , 65 ], Panax ginseng [ 73 , 74 , 75 ], and Hericium erinaceus [ 92 , 93 , 94 ] have been most studied. A total of 18 natural products have been identified across the studies, and their chemical structures are shown in Table 2 .…”

Section: Discussionmentioning

confidence: 99%

“…A recently published study reported that another subfamily member, FGF5, is also involved in regulating SC migration and adhesion [ 131 ]. Besides FGF-2 signaling, another study investigating polypeptides of A. bidentata revealed that the upregulation of NOX4/DUOX2-derived reactive oxygen species (ROS) production was responsible for promoting SC migration [ 44 ]. Excessive accumulation of ROS production has been linked to neurodegenerative disorders [ 132 ] and peripheral neuropathy [ 133 ], but moderate levels of ROS may prove beneficial by acting as signal messengers in regulating biological processes, including cell adhesion and migration [ 134 , 135 ].…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

Yow

Goh

Nyiew

et al. 2021

Cells

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Despite the progressive advances, current standards of treatments for peripheral nerve injury do not guarantee complete recovery. Thus, alternative therapeutic interventions should be considered. Complementary and alternative medicines (CAMs) are widely explored for their therapeutic value, but their potential use in peripheral nerve regeneration is underappreciated. The present systematic review, designed according to guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, aims to present and discuss the current literature on the neuroregenerative potential of CAMs, focusing on plants or herbs, mushrooms, decoctions, and their respective natural products. The available literature on CAMs associated with peripheral nerve regeneration published up to 2020 were retrieved from PubMed, Scopus, and Web of Science. According to current literature, the neuroregenerative potential of Achyranthes bidentata, Astragalus membranaceus, Curcuma longa, Panax ginseng, and Hericium erinaceus are the most widely studied. Various CAMs enhanced proliferation and migration of Schwann cells in vitro, primarily through activation of MAPK pathway and FGF-2 signaling, respectively. Animal studies demonstrated the ability of CAMs to promote peripheral nerve regeneration and functional recovery, which are partially associated with modulations of neurotrophic factors, pro-inflammatory cytokines, and anti-apoptotic signaling. This systematic review provides evidence for the potential use of CAMs in the management of peripheral nerve injury.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

Yow

Goh

Nyiew

et al. 2021

Cells

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“…Dual oxidase 2 (DUOX2) is an important NADPH oxidase catalytic subunit that regulates the production of ROS (14,15). It causes cellular inflammatory response by mediating epidermal keratinocytes by promoting the activation of NF-κB signals and inducing the upregulation of IL-8 and CCL20 (15). This suggests that DUOX2 may play a crucial role in UVB-induced photoaging and inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

DUOX2 participates in skin aging induced by UVB in HSF2 cells by activating NF‑κB signaling

et al. 2020

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Skin and in particular photoaging or premature aging, are caused by a variety of factors, including hormone imbalance and exposure to ultraviolet radiation. The aim of the present study was to explore the roles of Dual oxidase 2 (DUOX2) and related NF-κB signals in skin photoaging. Cell models of photoaging were constructed by irradiating human skin fibroblast lines (HSF2) with ultraviolet B (UVB) of different doses (0, 15, 30 and 60 mj/cm 2 ). The cell counting kit-8 (CCK8) was used to determine cell proliferation. Flow cytometry was used to determine the production of reactive oxygen species (ROS). A biochemical method was to determine the content of hydrogen peroxide, and the quantitative PCR (qPCR) was used to determine the expression of matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9), Col-Ⅰ and α-SMA in the cells. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Western blot analysis was performed to determine the expression of DUOX2, p65 and p-p65.The results showed that,UVB irradiation dose-and time-dependently inhibited the proliferation of HSF2 cells. Cellular inflammatory response, ROS production and hydrogen peroxide increase was promoted. Col-Ⅰ and α-SMA were downregulated, MMP2 and MMP9 were upregulated, and the phosphorylation of NF-κB p65 was promoted. The above indicators were all reversed by interference with DUOX2. Overexpression of DUOX2 has an effect that is similar to UVB irradiation, but the effects can be significantly weakened by NF-κB inhibitor, NAC. Upregulation of DUOX2 expression plays a crucial role in UVB-induced aging of HSF2 cells. The specific mechanism is related to the promotion of ROS production and cellular inflammatory response and activation of NF-κB signals.

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SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes

Guo

Chen

et al. 2020

Environmental Pollution

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Achyranthes bidentata polypeptides promotes migration of Schwann cells via NOX4/DUOX2-dependent ROS production in rats

Cited by 3 publications

References 37 publications

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

DUOX2 participates in skin aging induced by UVB in HSF2 cells by activating NF‑κB signaling

SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes

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