Achromobacter spp. prevalence and adaptation in cystic fibrosis lung infection

Veschetti, Laura; Boaretti, Marzia; Saitta, G; Mantovani, Rebeca Passarelli; Lleò, Maria M.; Sandri, Angela; Malerba, Giovanni

doi:10.1016/j.micres.2022.127140

Cited by 17 publications

(5 citation statements)

References 122 publications

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“…Veschetti ve ark. (20) KF'li 54 hastada kronik ve tekrarlayan enfeksiyonlara sebep olan Achromobacter izolatlarını karşılaştırdıklarında direnç genlerinde önemli bir fark olmadığını bildirmişlerdir. Ayrıca bu mikroorganizmanın antibiyotik direncinden sorumlu mekanizmalarının; beta laktamaz enzim üretimi, akış pompa sistemi veya antibiyotik hedefindeki değişiklikler gibi faktörlerle gerçekleştiğini ifade etmişlerdir.…”

Section: Discussionunclassified

Retrospective analysis of Achromobacter species isolated from cystic fibrosis and non-cystic fibrosis patients

et al. 2022

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Achromobacter türleri Gram negatif, katalaz, oksidaz ve sitrat pozitif, fermentatif olmayan bakterilerdir. Toplum kökenli ya da hastane kaynaklı enfeksiyonlara sebep olabilmektedir. Hem immünokompetan hem de immün yetmezlikli kişilerde enfeksiyonlara sebep olabilmekle birlikte kistik fibrozis (KF) hastalarını enfekte etmeleri durumunda, KF hastalarının akciğer fonksiyonlarını kötüleştirdiğinden ve daha sık pulmoner alevlenmeye neden olduğundan bu hasta grubunda özellikle önem taşımaktadır. Bu retrospektif çalışmada, Marmara Üniversitesi Eğitim ve Araştırma Hastanesi’nde 2017-2021 yıllarında Achromobacter türleri izole edilen hastaların verileri analiz edilmiştir. Altta yatan hastalıkların varlığına göre Achromobacter türlerinin izolasyon sıklığı, hastalara ait demografik veriler ve antimikrobiyal duyarlılık sonuçları irdelenmiştir. İzolatların tür düzeyinde tanımlaması, matriks ile desteklenmiş lazer desorpsiyon/iyonizasyon uçuş zamanı kütle spektrometresi (MALDI-TOF MS, VITEK MS, BioMérieux, Fransa) ile yapılmıştır. Antimikrobiyal duyarlılık testleri, disk difüzyon metodu ile çalışılmıştır. İstatistiksel analizler için SPSS (Statistical Package for Social Sciences) for Windows 24.0 programı kullanılmıştır. Toplam 148 hastadan 318 Achromobacter izolatı elde edilmiştir. Hastaların %29.7’si kistik fibrozis (KF); %70.3’ü ise KF dışı hastalar olmasına rağmen izolatların %51.6’sı KF hastalarına aittir (P=0.63). En sık gönderilen örnek türü, solunum yollarına ait örnekler olup (%78), KF hastalarında gönderilen örneklerin tümü solunum örneği iken; KF dışı hastalarda bu oran %54.5’tir (P

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Section: Discussionunclassified

Retrospective analysis of Achromobacter species isolated from cystic fibrosis and non-cystic fibrosis patients

et al. 2022

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“…[61][62][63][64] Autism has also been associated with both Achromobacter and Pseudomonas genera. 65,66 Both Achromobacter and Pseudomonas are linked to cystic fibrosis, which is another PCD that does not feature neurodegeneration; 67,68 Achromobacter was reported to exacerbate the disease, 69 and P. aeruginosa is a predominant pathogenic species that colonizes the lungs of CF patients. 70 A. xylosoxidans induced proteotoxicity in all our disease models (Figure 4), along with Pseudomonas, which displayed a notable increase in polyQ aggregation (Figure 4A, "Aggregates").…”

Section: Proteotoxic Bacteria Enhance the Aggregation And Toxicity Of...mentioning

confidence: 99%

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

Walker,

Bhargava,

Bucher

et al. 2023

Preprint

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Neurodegenerative protein conformational diseases (PCDs), such as Alzheimer's, Parkinson's, and Huntington's, are a leading cause of death and disability worldwide and have no known cures or effective treatments. Emerging evidence suggests a role for the gut microbiota in the pathogenesis of neurodegenerative PCDs; however, the influence of specific bacteria on the culprit proteins associated with each of these diseases remains elusive, primarily due to the complexity of the microbiota. In the present study, we employed a single-strain screening approach to identify human bacterial isolates that enhance or suppress the aggregation of culprit proteins and the associated toxicity in Caenorhabditis elegans expressing Abeta1-42, alpha-synuclein, and polyglutamine tracts. Here, we reveal the first comprehensive analysis of the human microbiome for its effect on proteins associated with neurodegenerative diseases. Our results suggest that bacteria affect the aggregation of metastable proteins by modulating host proteostasis rather than selectively targeting specific disease-associated proteins. These results reveal bacteria that potentially influence the pathogenesis of PCDs and open new promising prevention and treatment opportunities by altering the abundance of beneficial and detrimental microbes.

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“…A rare episode of acute, severe community-acquired bacterial skin-skin tissue infection by Achromobacter denitrificans is described, on the ground of the existing literature in this field. A. denitrificans has been widely isolated in natural environment, especially in soil and water, may be part of the normal flora of the ear and the gastrointestinal and respiratory tracts in some people, and, have been recognized as emerging pathogens causing a wide range of human infections in recent years [1][2][3]. However, infections of the skin of this emerging gram-negative pathogen: although intrinsically poorly virulent, it may be responsible of local, complicated disease manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…denitrificans is an emerging gram-negative non-fermenting rod has been primarily isolated from respiratory tract of people with cystic fibrosis, and recorded in sporadic reports as an opportunistic bacterial pathogen, especially in nosocomial settings, with catheter-related bacteremia and pneumonia as the most frequent clinical presentations. Since late 1990s its taxonomy changed [1][2][3], and it was distinguished from other environmental gram-negative bacilli like Alcaligenes xylosoxidans and Xanthomonas maltophilia, responsible for multiple site infections of the compromised host, and also showing an unpredictable profile of in vitro antibiotic susceptibility [1][2][3]. We herewith discuss a unique case of community-acquired A. denitrificans acute skin-skin structure infection (ABSSI).…”

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confidence: 99%

Severe Community - Acquired Achromobacter denitrificans Cellulitis

Mastroianni¹,

Sonia²,

Valeria³

et al. 2023

J Infect Dis Epidemiol

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Achromobacter is a genus of non-fermenting gram-negative bacteria, mainly isolated from the respiratory tract of people with cystic fibrosis, but recognized as the causal agent of different types of infections, especially in individuals and with chronic diseases and immune deficiency. Skin infections are very rare and not easy to manage also due to the intrinsic resistance to various antibiotics empirically used in the treatment of skin infections. In this short report, we intend to describe a rare case of Achromobacter denitrificans cellulitis with the result of an analysis of the cases described in the literature.

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Achromobacter spp. prevalence and adaptation in cystic fibrosis lung infection

Cited by 17 publications

References 122 publications

Retrospective analysis of Achromobacter species isolated from cystic fibrosis and non-cystic fibrosis patients

Retrospective analysis of Achromobacter species isolated from cystic fibrosis and non-cystic fibrosis patients

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

Severe Community - Acquired Achromobacter denitrificans Cellulitis

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