Achromatic miniature lens system for coherent Raman scattering microscopy

Mittal, Richa; Balu, Mihaela; Wilder‐Smith, Petra; Potma, Eric O.

doi:10.1364/boe.4.002196

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Several groups already work on miniaturization of the technology to transfer it to the clinical application. They report the development of a handheld prototype of a miniature multimodal CARS microscopefor in vivo imaging [29], [30] as well as fiber-based CARS microendoscope [31], [32] . A wearable SHG microscope was also presented [33] .…”

Section: Discussionmentioning

confidence: 99%

Label-free Imaging of Myocardial Remodeling in Atrial Fibrillation Using Nonlinear Optical Microscopy: A Feasibility Study.

Büttner

Galli

Husser

et al. 2018

Journal of Atrial Fibrillation

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Atrial fibrillation, characterized by rapid disorganized electrical activation of myocardium, is caused by and accompanied by remodeling of myocardial tissue. We applied nonlinear optical microscopy (NLOM) to visualize typical myocardial features and atrial fibrillation effects in order to test anon-destructive imaging technology that in principle can be applied in vivo.Coherent anti-Stokes Raman scattering, endogenous two-photon excited fluorescence, and second harmonic generation were used to inspect unstained human atrial myocardium from three patients who underwent surgical Cox-MAZE procedure with amputation of left atrial appendage. Using NLOM techniques, we collected detailrich pictures of unstained tissue that enable comprehensive characterization of myocardial characteristics like myocyte structure, collagen and lipofuscin deposition, intercalating disc width, and fatty degradation. Development of in vivo application of the NLOM technique may represent a revolutionary approach in characterizing atrial fibrillation associated myocardial remodeling with important implications for therapy individualization and monitoring.

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Section: Discussionmentioning

confidence: 99%

Label-free Imaging of Myocardial Remodeling in Atrial Fibrillation Using Nonlinear Optical Microscopy: A Feasibility Study.

Büttner

Galli

Husser

et al. 2018

Journal of Atrial Fibrillation

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“…Although commercial achromatic objectives have been widely used in benchtop CRS microscopes, they typically comprise multiple bulky lenses to correct aberrations. 17,18 For endoscopy, it is challenging to precisely fabricate and align miniature lenses due to their curved configuration and small diameter. As a result, typical endoscope lenses suffer from inferior optical quality and severe monochromatic and chromatic aberrations.…”

Section: Introductionmentioning

confidence: 99%

Coherent Raman scattering imaging with a near-infrared achromatic metalens

et al. 2021

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Miniature handheld imaging devices and endoscopes based on coherent Raman scattering are promising for label-free in vivo optical diagnosis. Toward the development of these small-scale systems, a challenge arises from the design and fabrication of achromatic and high-end miniature optical components for both pump and Stokes laser wavelengths. Here, we report a metasurface converting a low-cost plano–convex lens into a water-immersion, nearly diffraction-limited and achromatic lens. The metasurface comprising amorphous silicon nanopillars is designed in a way that all incident rays arrive at the focus with the same phase and group delay, leading to corrections of monochromatic and chromatic aberrations of the refractive lens, respectively. Compared to the case without the metasurface, the hybrid metasurface-refractive lens has higher Strehl ratios than the plano–convex lens and a tighter depth of focus. The hybrid metasurface-refractive lens is utilized in spectroscopic stimulated Raman scattering and coherent anti-Stokes Raman scattering imaging for the differentiation of two different polymer microbeads. Subsequently, the hybrid metalens is harnessed for volumetric coherent Raman scattering imaging of bead and tissue samples. Finally, we discuss possible approaches to integrate such hybrid metalens in a miniature scanning system for label-free coherent Raman scattering endoscopes.

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“…Novel instrumentation for optical molecular imaging is described for Second Harmonic Generation (SHG) microscopy coupled with polarization analysis [2], enabling rapid and accurate data collection using cost-effective components. For Raman-based instrumentation, a miniaturized lens assembly is presented that maintains high quality microscopy images while decreasing the size of coherent Raman scattering imaging probes [3]. Different optical interferometric approaches to detect the presence and concentration of plasmonic nanoparticle contrast agents are described and compared quantitatively in [4].…”

mentioning

confidence: 99%

Introduction: feature issue on optical molecular probes, imaging, and drug delivery

Campagnola

French

Georgakoudi

et al. 2014

Biomed. Opt. Express

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The editors introduce the Biomedical Optics Express feature issue "Optical Molecular Probes, Imaging, and Drug Delivery," which is associated with a Topical Meeting of the same name held at the 2013 Optical Society of America (OSA) Optics in the Life Sciences Congress in Waikoloa Beach, Hawaii, April 14-18, 2013. The international meeting focused on the convergence of optical physics, photonics technology, nanoscience, and photochemistry with drug discovery and clinical medicine. Papers in this feature issue are representative of meeting topics, including advances in microscopy, nanotechnology, and optics in cancer research.

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Achromatic miniature lens system for coherent Raman scattering microscopy

Cited by 5 publications

References 30 publications

Label-free Imaging of Myocardial Remodeling in Atrial Fibrillation Using Nonlinear Optical Microscopy: A Feasibility Study.

Label-free Imaging of Myocardial Remodeling in Atrial Fibrillation Using Nonlinear Optical Microscopy: A Feasibility Study.

Coherent Raman scattering imaging with a near-infrared achromatic metalens

Introduction: feature issue on optical molecular probes, imaging, and drug delivery

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