Achilles Tendon Augmented Repair Using Human Acellular Dermal Matrix: A Case Series

Cole, Windy; Samsell, Brian; Moore, Mark A.

doi:10.1053/j.jfas.2018.03.006

Cited by 22 publications

(21 citation statements)

References 27 publications

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“…There were 21 patients with good clinical and patient-reported short-term (24 weeks) results who returned to full activities in 12 weeks. In another case series of nine patients who underwent Achilles tendon repair with accellular dermal matrix augmentation, no re-ruptures or complications were reported in any of the patients with a minimum follow-up period of 2 years [35].…”

Section: Biological Scaffoldsmentioning

confidence: 91%

The Role of Scaffolds in Tendon Tissue Engineering

Vasiliadis

Katakalos

2020

JFB

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Tendons are unique forms of connective tissue aiming to transmit the mechanical force of muscle contraction to the bones. Tendon injury may be due to direct trauma or might be secondary to overuse injury and age-related degeneration, leading to inflammation, weakening and subsequent rupture. Current traditional treatment strategies focus on pain relief, reduction of the inflammation and functional restoration. Tendon repair surgery can be performed in people with tendon injuries to restore the tendon’s function, with re-rupture being the main potential complication. Novel therapeutic approaches that address the underlying pathology of the disease is warranted. Scaffolds represent a promising solution to the challenges associated with tendon tissue engineering. The ideal scaffold for tendon tissue engineering needs to exhibit physiologically relevant mechanical properties and to facilitate functional graft integration by promoting the regeneration of the native tissue.

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Section: Biological Scaffoldsmentioning

confidence: 91%

The Role of Scaffolds in Tendon Tissue Engineering

Vasiliadis

Katakalos

2020

JFB

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“…We expect the strength of the ADM to be sufficient to prevent bowstringing, given documented durability in hernia repair, superior capsular reconstruction for irreparable rotator cuff tears, and Achilles tendon repair augmentation. 15,16 We expect that ADM provides an antiadhesive surface and low gliding resistance similar to that of the native pulley system. Even in hostile environments, such as prior radiation and chronic inflammation, ADM can incorporate and take on the lubricating properties of surrounding tissues.…”

Section: Expected Outcomesmentioning

confidence: 99%

Pulley Release and Reconstruction With Acellular Dermal Matrix After Zone 2 Flexor Tendon Injury

Kurlander

Swanson

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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Zone 2 flexor tendon repair has been historically associated with poor outcomes, mainly due to stiffness. In an effort to minimize adhesions, accommodate flexor digitorum profundus and flexor digitorum superficialis bulk, and prevent bowstringing, we have developed a novel approach to flexor tendon repair that relies on aggressive flexor tendon pulley release and pulley reconstruction with acellular dermal matrix. This technique leverages the antiadhesive properties and high tensile strength of acellular dermal matrix to maximize gliding and prevent bowstringing. Here we describe the details of our technique and illustrate a case where this technique was employed.

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“…[10,11] It is reported that the acellular dermal matrix (ADM), commonly used as a replacement for skin grafts and a supplement for tissue defects, [12] has been applied for tendon augmentation in Achilles tendon repair and as tendon scaffold in tendon gap repair. [13][14][15] However, to our knowledge, the effects of using an ADM as the mechanical anti-adhesive barrier when repairing flexer tendon injuries have not been documented yet. In this study, we present the long-term outcomes of a randomized prospective study in which ADM was used to prevent postoperative adhesions after tendon injury.…”

Section: Introductionmentioning

confidence: 99%

Prevention of postoperative adhesions after flexor tendon repair with acellular dermal matrix in Zones III, IV, and V of the hand

Lee¹,

Ryoo²,

Shim³

2022

Medicine

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Background: Various techniques have been attempted for preventing postoperative flexor tendon adhesion, such as modification of suture technique, pharmacological agents, and mechanical barriers. However, there is no evidence of the efficacy of these methods in clinical settings. In this study, we present the long-term outcomes of a randomized prospective study in which acellular dermal matrix (ADM) was used to prevent postoperative adhesions after tendon injury in the hand.Methods: From January 2017 to January 2020, all patients with an acute single flexor tendon injury in hand Zones III, IV, or V were candidates. A single-digit, total tendon rupture repaired within 48 hours, from the index finger to the little finger, was included in the study. Patients were randomly allocated to either a control or ADM group. Complications and the range of movements were recorded. Functional outcomes and a patient satisfaction questionnaire were evaluated after 12 months following the tendon repair surgery. The present study is adhered to the CONSORT guidelines.Results: A total of 25 patients was enrolled in the study: 13 patients in the ADM group and 12 in the control group. According to Buck-Gramcko II criteria, the postoperative functional outcome score was 14.38 ± 1.71 in the ADM group and 13.08 ± 1.82 in the control group (P value = .0485). Patient satisfaction was recorded at 8.38 ± 1.44 in the ADM group and 7.08 ± 1.58 in the control group (P value = .0309), a significant difference. There were no differences in complications between the 2 groups. Conclusion:The beneficial effects of ADM after tendon repair were confirmed by improved postoperative functional outcome at flexor Zones III, IV, and V, preventing peritendinous adhesions and acting effectively as an anti-adhesive barrier.Abbreviations: ADM = acellular dermal matrix, HA = hyaluronic acid.

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Achilles Tendon Augmented Repair Using Human Acellular Dermal Matrix: A Case Series

Cited by 22 publications

References 27 publications

The Role of Scaffolds in Tendon Tissue Engineering

The Role of Scaffolds in Tendon Tissue Engineering

Pulley Release and Reconstruction With Acellular Dermal Matrix After Zone 2 Flexor Tendon Injury

Prevention of postoperative adhesions after flexor tendon repair with acellular dermal matrix in Zones III, IV, and V of the hand

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