Achillea wilhelmsii–Incorporated Chitosan@Eudragit Nanoparticles Intended for Enhanced Ulcerative Colitis Treatment

Maleki, Hassan; Doostan, Maryam; Farzaei, Mohammad Hosein; Seifi, Parisa; Miraghaee, Shahram; Doostan, Mahtab

doi:10.1208/s12249-023-02568-x

Cited by 5 publications

(3 citation statements)

References 59 publications

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“…Also, the positive charge is possibly attributed to the residual -NH 3+ in chitosan chains on the surface of NPs. 42…”

Section: Particle Size Morphology and Zeta Potentialmentioning

confidence: 99%

“…The peaks at 2937, 3387, and 3562 cm -1 also appeared, matching C-H stretching, −OH and −NH 2 stretching bonds in the chitosan structure. 42,45 In the spectrum of naringin-loaded chitosan NPs (Figure 2(c)), the prominent bands of naringin and chitosan appeared in the loaded NPs. Further, the presence of distinct peaks corresponding to naringin in the spectrum of the loaded chitosan NPs indicated the successful encapsulation of naringin without any detrimental chemical interactions.…”

Section: Ftir Characterizationmentioning

confidence: 99%

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Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Safari,

Fakhri,

Maleki

et al. 2024

Journal of Bioactive and Compatible Polymers

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Peripheral neuropathies are associated with various detrimental complications, leading to life-debilitating disorders, including neuropathic pain. Hence, the current study aimed to incorporate naringin, a potential natural component, into chitosan nanoparticles (NPs) to ameliorate the complications resulting from chronic constriction injury (CCI) induced painful neuropathy. The prepared NPs had a particle size of 220 nm and PDI = 0.37, with relatively spherical morphology and zeta potential of +41.5 mV. The relevant analyses indicated the loading and high encapsulation efficiency of naringin into the NPs as well as a prolonged release of naringin. The anti-neuropathic evaluations of chronic constriction injury (CCI)-induced rats treated with naringin-loaded NPs (10 mg/kg) remarkably ameliorated hyperalgesia and cold allodynia. In addition, the treatment with naringin-loaded NPs led to improvements in sensory and locomotor impairment, as evidenced by changes in behavioral parameters such as reduced paw licking, increased rearings, and enhanced crossings. The NPs treatment significantly attenuated the elevated levels of nitrite and restored the reduced glutathione level in the serum of CCI-induced rats. Moreover, histopathological analysis exhibited regeneration of the sciatic nerve injury through reducing myelin degeneration, axonal swelling, and nerve fiber derangement. Therefore, these findings suggest that the naringin-loaded chitosan NPs has promising pharmacological activities for the treatment of neuropathic pain sufferers.

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“…Also, the positive charge is possibly attributed to the residual -NH 3+ in chitosan chains on the surface of NPs. 42…”

Section: Particle Size Morphology and Zeta Potentialmentioning

confidence: 99%

Section: Ftir Characterizationmentioning

confidence: 99%

Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Safari,

Fakhri,

Maleki

et al. 2024

Journal of Bioactive and Compatible Polymers

Self Cite

View full text Add to dashboard Cite

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“…In addition, pH-responsive nanomedicines can accurately target the gut for IBD treatment, such as methotrexate-loaded HA-CS/Eudragit® S100/Polylactic acid-glycolic acid copolymer NPs and Achillea wilhelmsii C. Koch-loaded Eudragit S100-coated chitosan NPs. 174 , 175 Iron-based nano-biocomposite impregnated alginate formulation and ferulic acid-derived lignin nanoparticle disintegrate at colon pH, which achieves the delivery of targeting colon. 176 , 177 Curcumin, decorated with a prussian blue analog can be released in inflammatory tissue (acidic environment), which promotes the polarization of M2 macrophages and the clearance of ROS.…”

Section: Ibd Treatments: Based On Experimentsmentioning

confidence: 99%

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Bai,

Wang,

et al. 2024

Science Progress

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence, such as Crohn's disease and ulcerative colitis. The accurate etiology and pathogenesis of IBD remain unclear, and it is generally believed that it is related to genetic susceptibility, gut microbiota, environmental factors, immunological abnormalities, and potentially other factors. Currently, the mainstream therapeutic drugs are amino salicylic acid agents, corticosteroids, immunomodulators, and biological agents, but the remission rates do not surpass 30–60% of patients in a real-life setting. As a consequence, there are many studies focusing on emerging drugs and bioactive ingredients that have higher efficacy and long-term safety for achieving complete deep healing. This article begins with a review of the latest, systematic, and credible summaries of the pathogenesis of IBD. In addition, we provide a summary of the current treatments and drugs for IBD. Finally, we focus on the therapeutic effects of emerging drugs such as microRNAs and lncRNAs, nanoparticles-mediated drugs and natural products on IBD and their mechanisms of action.

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Bioinspired and bioderived nanomedicine for inflammatory bowel disease

Gazzi,

Gelli,

Aleandri

et al. 2024

WIREs Nanomed Nanobiotechnol

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Due to its chronic nature and complex pathophysiology, inflammatory bowel disease (IBD) poses significant challenges for treatment. The long‐term therapies for patients, often diagnosed between the ages of 20 and 40, call for innovative strategies to target inflammation, minimize systemic drug exposure, and improve patients' therapeutic outcomes. Among the plethora of strategies currently pursued, bioinspired and bioderived nano‐based formulations have garnered interest for their safety and versatility in the management of IBD. Bioinspired nanomedicine can host and deliver not only small drug molecules but also biotherapeutics, be made gastroresistant and mucoadhesive or mucopenetrating and, for these reasons, are largely investigated for oral administration, while surprisingly less for rectal delivery, recommended first‐line treatment approach for several IBD patients. The use of bioderived nanocarriers, mostly extracellular vesicles (EVs), endowed with unique homing abilities, is still in its infancy with respect to the arsenal of nanomedicine under investigation for IBD treatment. An emerging source of EVs suited for oral administration is ingesta, that is, plants or milk, thanks to their remarkable ability to resist the harsh environment of the upper gastrointestinal tract. Inspired by the unparalleled properties of natural biomaterials, sophisticated avenues for enhancing therapeutic efficacy and advancing precision medicine approaches in IBD care are taking shape, although bottlenecks arising either from the complexity of the nanomedicine designed or from the lack of a clear regulatory pathway still hinder a smooth and efficient translation to the clinics.This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Achillea wilhelmsii–Incorporated Chitosan@Eudragit Nanoparticles Intended for Enhanced Ulcerative Colitis Treatment

Cited by 5 publications

References 59 publications

Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Bioinspired and bioderived nanomedicine for inflammatory bowel disease

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