Achieving highly water-soluble and luminescent gold nanoclusters modified by β–cyclodextrin as multifunctional nanoprobe for biological applications

Wang, Yuyao; Guo, Hao; Zhang, Yixia; Tai, Feifei; Wang, Yuxuan; Dong, Qingchen; Nie, Yu; Zhao, Qiang; Wong, Wai Yeung

doi:10.1016/j.dyepig.2018.05.015

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…Gold nanoclusters (AuNCs) are highly luminescent. Wang et al (2018 ) enhanced their water solubility by complexing it with β-CD. The size of the β-CD-modified AuNCs measured using the high-resolution transmission electron microscope (HRTEM) was around 3.14 nm.…”

Section: Cyclodextrin Nanoparticles For Therapy and Diagnostic Applic...mentioning

confidence: 99%

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Karthic

Roy

Lakkakula

et al. 2022

Front. Cell Dev. Biol.

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Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokinetic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems have the caliber to improve the solubility and biocompatibility of various such chemical compounds. In this regard, cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility, and stability, whereas CDs supramolecular chemical compatibility renders it to be highly receptive to various kinds of functionalization. Therefore combining physical, chemical, and bio-engineering approaches at nanoscale to specifically target the tumor cells can help in maximizing the tumor damage without harming non-malignant cells. Numerous combinations of CD nanocomposites were developed over the years, which employed photodynamic, photothermal therapy, chemotherapy, and hyperthermia methods, particularly targeting cancer cells. In this review, we discuss the vivid roles of cyclodextrin nanocomposites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.

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Section: Cyclodextrin Nanoparticles For Therapy and Diagnostic Applic...mentioning

confidence: 99%

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Karthic

Roy

Lakkakula

et al. 2022

Front. Cell Dev. Biol.

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“…Ultrafine metal nanoclusters (AgNCs and AuNCs, etc.) with excellent luminescence properties exhibit outstanding performance in analyzing, sensing, and bioimaging. − AuNCs stand out in bioimaging on account of their high biocompatibility, excellent photostability, and large Stokes shift. − However, the luminescent quantum yield (QY) of AuNCs is generally lower than that of quantum dots and organic dyes. − To date, there are still few reports on AuNCs with QY over 20% in aqueous solution, which severely limits their applicability in bioimaging and luminescence detection. − In view of this, several strategies such as doping with metal ions (Ag and Cu), − host–guest assembly, − and embedding in polymer matrixes , have been adopted to enhance luminescent performances. Among them, the host–guest assembly strategy is an effective and simple measure to suppress the nonradiative transitions of AuNCs via multiple noncovalent interactions between the rigid host macrocycles and the surface ligands of AuNCs.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

Jiang

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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The high biocompatibility and excellent photostability of Au nanoclusters (AuNCs) make them stand out in the bioimaging of nanoparticles. However, the low quantum yield and inferior targeting ability of water-soluble AuNCs greatly limit their biological applications. In this study, we designed and synthesized multifunctional host polymers PolySC 4 AP and FGGC@AuNCs to fabricate PolySC 4 AP/FGGC@AuNC assemblies via a host−guest interaction based on SC 4 (sulfonatocalix[4]arene) and positively charged FGGC ligands (phenylalanine-glycine-glycine-cysteine). Owing to the host−guest assembly strategy and rigid polymer matrix, the quantum yield of FGGC@AuNCs was significantly promoted from 7.0 to 35.3%, accompanied by considerable morphological changes of FGGC@AuNCs. Moreover, PolySC 4 AP/ FGGC@AuNCs could monitor the location of mitochondria along with R (Pearson's correlation coefficients) value for the colocalization as high as 0.9605, which provided a novel strategy for targeted bioimaging with luminophore.

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“…Gold nanoclusters with small diameters and aggregated AuNP have also found to be luminescent in nature (Gan et al, 2016;Goswami et al, 2016;Saini et al, 2017;J. Wang et al, 2018a;Y. Wang et al, 2018b;Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Luminescent Gold-Zinc Oxide Nanocomposites: Cell Imaging and Visible Light–Induced Dye Degradation

et al. 2021

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Green synthesis of gold-zinc oxide (Au-ZnO) nanocomposite was successfully attempted under organic solvent–free conditions at room temperature. Prolonged stirring of the reaction mixture introduced crystallinity in the ZnO phase of Au-ZnO nanocomposites. Luminescence properties were observed in these crystalline Au-ZnO nanocomposites due to in situ embedding of gold nanoparticles (AuNP) of 5–6 nm diameter on the surface. This efficient strategy involved the reduction of Au(III) by Zn(0) powder in aqueous medium, where sodium citrate (NaCt) was the stabilizing agent. Reaction time and variation of reagent concentrations were investigated to control the Au:Zn ratio within the nanocomposites. The reaction with the least amount of NaCt for a long duration resulted in Au-ZnO/Zn(OH)2 nanocomposite. X-ray photoelectron spectroscopy (XPS) confirmed the formation of Zn(OH)2 and ZnO in the same nanocomposite. These nanocomposites were reconnoitered as bioimaging materials in human cells and applied for visible light–induced photodegradation of rhodamine-B dye.

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Achieving highly water-soluble and luminescent gold nanoclusters modified by β–cyclodextrin as multifunctional nanoprobe for biological applications

Cited by 19 publications

References 41 publications

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

Green Synthesis of Luminescent Gold-Zinc Oxide Nanocomposites: Cell Imaging and Visible Light–Induced Dye Degradation

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