Achieving Clinical Remission for Patients With Rheumatoid Arthritis

Aletaha, Daniel; Smolen, Josef S.

doi:10.1001/jama.2018.21249

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…The authors of ARTIC and TASER have clearly highlighted the need for further work before US could be considered for guiding treatment management, including DMARDs de-escalation, in patients with RA [79]. A feasible and standardized US protocol, which could potentially be integrated into a clinical-centred monitoring strategy, is the 'conditio sine qua non' to improve the reliability and clinical usefulness of US in the follow-up of patients with RA.…”

Section: Can Ultrasound Help Guide Treatment In Rheumatoid Arthritis mentioning

confidence: 99%

The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum

et al. 2020

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Purpose of Review Rheumatoid arthritis (RA) is no longer considered a fixed phenotype but rather a disease continuum. This review outlines the current and potential value of applying ultrasound (US) along this continuum: from the prediction of progression to RA in at-risk individuals, to confirmation of the early diagnosis of RA, as well as the consideration of differential diagnoses, and the use in disease monitoring and defining remission. Recent Findings In individuals at-risk of RA (i.e., positive autoantibodies with symptoms but without synovitis), US has shown a promising predictive value for the development of clinical arthritis, providing the opportunity to improve risk stratification (and disease prevention) of these individuals. The detection of inflammation on US in patients with early undifferentiated arthritis, in which a definite diagnosis cannot be reached, could predict evolution to persistent arthritis, mostly RA. This, in addition to the US potential ability to identify disease specific patterns for different rheumatic conditions, might facilitate early diagnosis and, therefore, improve the management of patients with RA, or other types of inflammatory arthritides. US has also demonstrated the capability to predict radiographic progression, and relapse risk after treatment discontinuation, in RA patients in remission according to the clinical instruments, raising implications in the management, including therapy discontinuation, of these patients. Summary US has an undeniable value in the management of patients at different stages along the RA continuum. Further research is needed to identify which groups of patients benefit the most from US imaging.

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Section: Can Ultrasound Help Guide Treatment In Rheumatoid Arthritis mentioning

confidence: 99%

The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum

et al. 2020

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“…However, the requirement for US joint assessment is not advisable to integrate a disease activity instrument, such as SLE-DAS, as it would constitute a major barrier for its practicality. Importantly, previous studies did not find any added value of systematic joint US assessment for treatment decision in chronic arthritis 5–7…”

mentioning

confidence: 93%

Response to: ‘Assessment of responsiveness of the musculoskeletal component of SLE-DAS in an independent cohort’, by Hassan et al

et al. 2019

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“…[ 1 , 2 , 3 , 4 , 5 ] The pathogenesis of RA involves a variety of cytokines and molecules, and its exact etiology is still unclear. [ 6 , 7 , 8 , 9 , 10 , 11 ] The treatment of RA mainly depends on non‐steroidal anti‐inflammatory drugs (NSAIDs) and disease‐modifying anti‐rheumatic drugs (DMARDs) and glucocorticoids, [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ] which mainly focus on disease remission (alleviating pain and swelling), inhibiting inflammatory response and maintaining daily physical function. [ 19 , 20 , 21 ] But the efficacy of existing drugs is largely limited by their low bioavailability, low specificity, and high resolution rate, these drugs usually require frequent and high doses, but have high‐risk side effects.…”

Section: Introductionmentioning

confidence: 99%

Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis

Wang

Gao

et al. 2022

Advanced Science

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The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual‐targeted synergistic effect on collagen‐induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual‐target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR‐II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system.

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Achieving Clinical Remission for Patients With Rheumatoid Arthritis

Cited by 17 publications

References 18 publications

The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum

The Role of Musculoskeletal Ultrasound in the Rheumatoid Arthritis Continuum

Response to: ‘Assessment of responsiveness of the musculoskeletal component of SLE-DAS in an independent cohort’, by Hassan et al

Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis

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