Achievements of rheumatology in the XXI century: contribution of Russian rheumatology

Abstract

Rheumatology is one of the most rapidly developing medical specialties, which effectively adapts achievements and contributes to the progress of the world fundamental and clinical medical science [1]. Such immuno-inflammatory rheumatic diseases (IVRS) both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are not only the most severe chronic inflammatory human diseases, but also “models” for studying the fundamental mechanisms of pathogenesis and approaches to pharmacotherapy of other diseases associated with the development of autoimmunity and/or auto-inflammation. The relevance of the problem of IVR for modern medicine is determined by their high prevalence in the population, the difficulty of early diagnosis, the rapid development of disability and an unfavorable life prognosis. Deciphering the mechanisms of immunopathogenesis, improving diagnostics, molecular taxonomy, developing approaches to prevention, searching for new “targets” of IVR therapy based on “omix” technologies and artificial intelligence are among the priority areas of biology and medicine of the XXI century.