Achievements and Limits on the Controlled Release of a Drug from a Textile Fabric to Dermis

Abstract

The paper presents the overall results of theoretical achievements and experimental details when designing a material for a textile fabric, which releases a drug for a specific pathology. It presents the conclusions of the researches on the development of textile support as an anti-allergic, anti-fungal and anti-psoriasis type, but also on toxicological, biocompatibility and therapeutic issues for establishing the amount of drug needed for the trans-dermal diffusion. This paper estimates the possibility of applying a cyclodextrin (Cyc) on a textile surface to form temporary reservoirs by complexing and subsequently releasing the drug under the action of cutaneous stimuli. One refers to the achievements of authors, and works submitted by other research groups in the area of textile substrates used as implant or underwear worn next to the skin. The results are analyzed both as a scientific communication and the possible application for a potential current industrial processing.

Sol–Gel Treatment of Textiles for the Entrapping of an Antioxidant/Anti-Inflammatory Molecule: Functional Coating Morphological Characterization and Drug Release Evaluation

“…Indeed, textile fabrics, thanks to their biocompatibility, breathing structure and absorptive capacity, are of great interest as a medium (for ex vivo applications) for controlled release of drugs, active principles or aroma substances of particular comfortability [10]. Several examples are nowadays in common use, such as the well-known transdermal patches or textile costumes, generally characterized by different layers in which the release of a specific drug substance, deposited on the textile surface, is activated by stimuli such as temperature, humidity, enzyme, perspiration types or friction [11].…”

“…Indeed, this administration represents an attractive and easier therapy for the patient due to its efficacy since the drug avoids both the digestive apparatus and the hepatic metabolism that reduce the concentration of the drug. Furthermore, it requires lower dosages due to the higher diffusion through tissues, which correspond to lower social costs of therapies [11]. On the other hand, the disadvantages are related to the diffusion rate of the drug as function of its molecular structure and body surface administration [11].…”

“…Furthermore, it requires lower dosages due to the higher diffusion through tissues, which correspond to lower social costs of therapies [11]. On the other hand, the disadvantages are related to the diffusion rate of the drug as function of its molecular structure and body surface administration [11]. Different methods have been employed in order to develop better textile-based delivery systems (i.e., bandages, patches), with good controllability, biocompatibility and active species entrapment/release by use of host-guest molecules (cyclodextrins [12], aza-crown ethers, fullerenes) or doping functional molecules (ion-exchange; drug-loaded hollow; nanoparticles; bioactive) [10].…”