Achievement of near-normal body weight as the prerequisite to normalize sex hormone-binding globulin concentrations in massively obese men

Pasquali, Renato; Vicennati, Valentina; Scopinaro, Nicola; Marinari, Giuseppe M.; Simonelli, Anna; Flamia, R.; Casimirri, Francesco; Gagliardi, L

doi:10.1038/sj.ijo.0800351

Cited by 36 publications

(16 citation statements)

References 12 publications

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“…Low levels of SHBG have been associated with obesity (26), and weight loss in obese men has normalized SHBG levels (33). It has been suggested that SHBG levels probably are related to general metabolic factors.…”

Section: Variation With Anthropometrymentioning

confidence: 99%

The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study

et al. 2003

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Objective: To study whether lifestyle factors and/or chronic disease are associated with the age-related decline of total and free testosterone in men, or if these factors might be associated with the variation of total and free testosterone but not with their age-related decline. Design: A population-based, cross-sectional study was used. Methods: Total testosterone and sex hormone binding globulin (SHBG) levels were analyzed and free testosterone levels were calculated in 1563 men participating in the Tromsø study in 1994/1995. Anthropometric characteristics were also measured and two standardized questionnaires completed, including lifestyle factors and medical history. The data were analyzed with multiple linear regression analysis of covariance, and logistic regression. Results: Total and free testosterone were inversely associated (P ¼ 0.001 and P , 0.001), while SHBG was positively associated (P , 0.001) with age. Body mass index (BMI) was inversely associated with total (P , 0.001) and free (P ¼ 0.016) testosterone and SHBG (P , 0.001). Both total and free testosterone were positively associated with tobacco consumption (P , 0.001 and P ¼ 0.004) and total testosterone was positively associated with coffee consumption (P , 0.001). SHBG was positively associated with smoking (P ¼ 0.004) and coffee consumption (P , 0.001). Men who reported having had a stroke or having a cancer diagnosis had lower levels of total testosterone (P , 0.001 and P , 0.01) and free testosterone (P , 0.01). Conclusions: BMI and smoking are independent contributors to the variation of total and free testosterone and SHBG levels, and coffee consumption to the variation of total testosterone and SHBG. Thus, lifestyle factors can have a direct effect on circulating levels of free endogenous sex hormones and to total levels due to the effect on SHBG levels.

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Section: Variation With Anthropometrymentioning

confidence: 99%

The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study

et al. 2003

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“…6,[10][11][12] Furthermore, it also has been demonstrated that not only BPD, but also other bariatric operations, may result in substantial clinical improvement in patients with type 2 diabetes. 7,[11][12][13][14][15][16][17][18][19][20][21] Since many of these procedures controlled diabetes in obese and nonobese individuals, which procedure is best? To find the answer, we studied the effect of ileal transposition (IT) and BPD in Goto-Kakizaki (GK) rats, the most widely used animal model of nonobese type 2 diabetes.…”

mentioning

confidence: 99%

Resolution of diabetes mellitus by ileal transposition compared with biliopancreatic diversion in a nonobese animal model of type 2 diabetes

Zhang

Wang²,

Cheng³

et al. 2011

Can J Surg

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Background: It has been demonstrated that biliopancreatic diversion (BPD) and ileal transposition (IT) effectively induce weight loss and long-term control of type 2 diabetes in morbidly obese individuals. It is unknown whether the control of diabetes is better after IT or after BPD. The objective of this study was to investigate the effects of IT and BPD on the control of diabetes in an animal model. Methods:We performed IT and BPD on 10-to 12-week-old Goto-Kakizaki rats with a spontaneous nonobese model of type 2 diabetes, and we performed a series of detection. The rats were observed for 24 weeks after surgery.Results: Animals who underwent IT and BPD demonstrated improved glucose tolerance, insulin sensitivity and the secretion of glucagon-like peptide-1 compared with the sham-operated animals. Furthermore, IT resulted in a shorter duration of surgery and better postoperative recovery than BPD. Conclusion:This study provides strong evidence for the crucial role of the hindgut in the resolution of diabetes after duodenum-jejunum bypass or IT. We confirmed that IT was associated with better postoperative recovery than BPD and had a similar control of diabetes as BPD in nonobese animals with type 2 diabetes.Contexte : Il a été démontré que la dérivation biliopancréatique (DBP) et la transposition iléale (TI) sont efficaces pour faire perdre du poids et permettent de contrôler à long terme le diabète de type 2 chez les personnes atteintes d'obésité morbide. On ne sait pas si le contrôle du diabète est meilleur après la TI ou après la DBP. Cette étude visait à analyser les effets de la TI et de la DBP sur le contrôle du diabète dans un modèle animal.Méthodes : Nous avons pratiqué une TI et une DBP sur des rats Goto-Kakizaki âgés de 10 à 12 semaines avec un modèle non obèse spontané de diabète de type 2, et nous avons procédé à une série de détections. Les rats ont été observés pendant 24 semaines après l'intervention chirurgicale. Résultats :Chez les animaux qui ont subi une TI et une DBP, la tolérance au glucose, la sensibilité à l'insuline et la sécrétion de peptide-1 de type glucagon a augmenté comparativement à ceux qui ont subi une opération fictive. De plus, pour la TI, l'intervention chirurgicale a été de moindre durée et le rétablissement postopératoire a été meilleur, par rapport à la DBP. Conclusion :Cette étude démontre solidement le rôle crucial que joue l'intestin postérieur dans l'élimination du diabète après un pontage duodénojéjunal ou une transposition iléale. Nous avons confirmé que la TI était associée à un meilleur rétab-lissement après l'intervention que la DBP et permettait de contrôler le diabète de la même façon que la DBP chez les animaux non obèses atteint de diabète de type 2. Diabetes mellitus presently affects more than 170 million people worldwide, with an increase of at least 50% estimated for 2010.1 Prevalence of the disease is expected to reach about 300 million by 2025.2 As the population with type 2 diabetes increases, so does the prevalence of life-threatening complications. By...

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“…48,49 Moreover, achievement of near-normal body weight can lead to normalisation of SHBG concentrations in massively obese men. 50 Nevertheless, determination of the relative importance of these bidirectional effects in our cohort is not possible as there could be differences in short-and long-term relationships between adiposity and testosterone.…”

Section: Discussionmentioning

confidence: 98%

Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency

Allan¹,

Peverill²,

Strauss³

et al. 2011

Asian J Androl

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The decline in serum testosterone in ageing men may be mediated in part by obesity; however, it is uncertain which measure of adiposity is most closely associated with testosterone levels. We have examined the relationships of age, adiposity and testosterone levels in ageing men with symptoms consistent with hypoandrogenism but who were otherwise in good health. We conducted a cross-sectional study of non-smoking men aged o54 years recruited from the community and who were free of cancer or serious medical illness. Height (Ht), weight and waist circumference (WC) were measured, and body mass index (BMI) and waist-to-height (WHt) ratio were calculated. Two morning blood samples were collected for measurement of total testosterone (TT), sex hormone binding globulin (SHBG) and luteinizing hormone (LH). Free testosterone (cFT) was calculated. Multivariate linear regression analysis was performed to assess their relationship with measures of adiposity. Two hundred and seven men aged 54-86 years were studied. On univariate analysis WHt ratio was more strongly correlated with TT and cFT than either WC or BMI. Furthermore, in models of TT and cFT, the addition of Ht to WC resulted in an increase in the magnitude of the regression coefficients for both WC (inverse correlate) and Ht (positive correlate), with the contributions of both WC and Ht both being significant (P,0.05 for all). In conclusion, WHt ratio is the best anthropometric predictor of both TT and cFT in this group of healthy but symptomatic ageing men.

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Achievement of near-normal body weight as the prerequisite to normalize sex hormone-binding globulin concentrations in massively obese men

Cited by 36 publications

References 12 publications

The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study

The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study

Resolution of diabetes mellitus by ileal transposition compared with biliopancreatic diversion in a nonobese animal model of type 2 diabetes

Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency

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