Achalasia due to eosinophil infiltration: Fact or fiction?

Man, Fernando; Chiocca, J.C

doi:10.1007/bf01308622

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…The underlying cause or etiology of achalasia remains unknown; however, the role of eosinophils has been speculated [12]. In a study that examined the specimens from 42 patients who underwent an esophagectomy for achalasia, all specimens were found to have loss of myenteric ganglion cells, collagenous replacement of myenteric nerves, muscular hypertrophy of the muscularis propria; furthermore, over half of the specimens were noted to have eosinophilic infiltration in the muscularis propria [13].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia

Cheung

Hachem

Lai

2016

Clin J Gastroenterol

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Idiopathic hypereosinophilic syndrome (HES) is a rare diagnosis defined by the World Health Organization as a persistent eosinophilia for 6 months and resulting in end-organ dysfunction. While many patients present with nonspecific symptoms, others will present with symptoms of the affected organs, most commonly those involving the heart, skin, or nervous system. Gastrointestinal or liver involvement is estimated to affect up to one-third of patients with HES, although patients with clinically significant disease are limited to case reports. This is the first report of a patient presenting with hepatitis and achalasia related to idiopathic HES.

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Section: Discussionmentioning

confidence: 99%

Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia

Cheung

Hachem

Lai

2016

Clin J Gastroenterol

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“…Proposed mechanisms include degeneration or loss of nerve cells located in the dorsal motor nucleus of the vagus nerve, the myenteric plexus, or both sites (17)(18)(19)(20)(21)(22). Inflammatory infiltration around the myenteric plexus and esophageal smooth muscle has been described (21)(22)(23)(24)(25). Eosinophilic infiltration with degranulation and release of the neurotoxic and cytotoxic protein, eosinophilic cationic protein, may cause neuronal damage that leads to the development of achalasia (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Achalasia in an Adolescent With Fabry Disease

Field,

Ostrov,

Devenyi

et al. 2001

J. pediatr. gastroenterol. nutr.

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“…Histologic observations suggest that neuronal injury may occur at multiple levels: the myenteric plexus, along the vagus nerve and its branches, and/or in the dorsal motor nucleus of the vagus nerve (19)(20)(21)(22)(23)(24)(25).…”

Section: Discussonmentioning

confidence: 99%