Achalasia and Esophageal Carcinoma

Achalasia complicated by oesophageal squamous cell carcinoma: a prospective study in 195 patients.

“…The mean age at diagnosis of the oesophageal carcinoma was 68 years (37, 77, and 89 years). The mean period between the onset of dysphagia and the diagnosis of the tumour was 17 years (19,28, and 5 years); the mean interval between the diagnosis of achalasia and carcinoma was 5*7 years (5,8, and 4 years). The incidence of oesophageal squamous cell carcinoma in this series (3.4/1000 patients per year) is significantly higher than the statistically expected incidence (0-104/1000 patients per year) using age and sex specific incidence data from the population of the Netherlands (Poisson statistics: p<O0OOl).…”

“…An increased risk of developing oesophageal carcinoma in patients with long standing aschalasia has been reported by several authors, with incidences varying widely from 1-7 to 20%. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] This was not confirmed, however, in a prospective study by Chuong et al, who found no case of carcinoma in 91 patients with achalasia followed up over 6 5 years. '9 By the time symptoms of carcinoma of the oesophagus are evident over and above the dysphagia of achalasia, the tumour is usually advanced.…”

Original article: Expression of p53 as predictor for the development of esophageal cancer in achalasia patients

“…The reported risks for esophageal carcinoma vary widely between different studies. Several autopsy studies have reported an esophageal neoplasia prevalence of over 20% in achalasia patients at the time of death 9–11 . Wychulis et al.…”

Über die Narbenkarzinome des Ösophagus

“…Die einige Dezennien betragenden Zeitintervalle zwischen Primärscha-den und Karzinomentstehung decken sich überraschend mit der wirksamen Expositionsdauer mancher bekannter karzinogener Faktoren (5). Auf die statistischen Argumentationen wollen wir nicht näher eingehen, sondern verweisen nur auf entsprechende Literaturangaben (1,3,4,6,7,8,11,13,17,19).…”

“…Die entsprechende Operation der Stenose bedeutet gleichzeitig die Verhütung einer krebsigen Umwandlung. [13]) um Plattenepithelkarzinome. Die in der durch die peptische Ösophagitis hervorgerufenen Stenose entstehenden bösartigen Tumoren sind mit den Narbenkarzinomen der ätzmittelbeding-ten Ösophagusstrikturen in Analogie zu bringen.…”