Acetylsalicylic Acid–Primus Inter Pares in Pharmacology

Fijałkowski, Łukasz; Kowalska, Magdalena; Grześk, Grzegorz; Koech, Frankline Kiptoo; Nowaczyk, Alicja

doi:10.3390/molecules27238412

Cited by 11 publications

(7 citation statements)

References 217 publications

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“…The drug can also be administered in uniform rectal suppositories, through injection, by absorption via the skin, or as an inhalation. The effectiveness and action of the drug depend on the selected mode of administration and the form of the drug used (Figure 3) [53,54].…”

Section: Bioavailability Of Drugs: Basic Concepts and Controlling Fac...mentioning

confidence: 99%

The Bioavailability of Drugs—The Current State of Knowledge

Stielow,

Witczyńska,

Kubryń

et al. 2023

Molecules

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Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients’ bodies is essential to ensure proper and safe treatment. This publication aims to highlight the relevance of drug bioavailability research and its importance in therapy. In addition to biochemical activity, bioavailability also plays a critical role in achieving the desired therapeutic effects. This may seem obvious, but it is worth noting that a drug can only produce the expected effect if the proper level of concentration can be achieved at the desired point in a patient’s body. Given the differences between patients, drug dosages, and administration forms, understanding and controlling bioavailability has become a priority in pharmacology. This publication discusses the basic concepts of bioavailability and the factors affecting it. We also looked at various methods of assessing bioavailability, both in the laboratory and in the clinic. Notably, the introduction of new technologies and tools in this field is vital to achieve advances in drug bioavailability research. This publication also discusses cases of drugs with poorly described bioavailability, providing a deeper understanding of the complex challenges they pose to medical researchers and practitioners. Simultaneously, the article focuses on the perspectives and trends that may shape the future of research regarding bioavailability, which is crucial to the development of modern pharmacology and drug therapy. In this context, the publication offers an essential, meaningful contribution toward understanding and highlighting bioavailability’s role in reliable patient treatment. The text also identifies areas that require further research and exploration.

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Section: Bioavailability Of Drugs: Basic Concepts and Controlling Fac...mentioning

confidence: 99%

The Bioavailability of Drugs—The Current State of Knowledge

Stielow,

Witczyńska,

Kubryń

et al. 2023

Molecules

Self Cite

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“…One of the earliest synthesized drugs was aspirin (AAS), a notable representative of non-steroidal anti-inflammatory drugs (NSAIDs), and since its inception, it has held a prominent position as one of the most widely used analgesics. Moreover, it remains unparalleled as the most prevalent drug in the modern era ( Fijałkowski et al ., 2022 ). Its continued global consumption can be attributed to its diverse applications in the medical field, encompassing analgesic and antipyretic properties ( Fuster & Sweeny, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of major analgesics on male fertility: A systematic literature review

Capelo,

Monteiro,

Anastácio

2024

JBRA

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Objective: To verify, based on a systematic literature review, the effects of the main analgesics on male fertility.Data Sources: The studies were analyzed from the PubMed, SciELO and LILACS databases.Study Selection: The articles selected for the present review included: cohort studies; cross-sectional studies, clinical trials; complete studies; studies with animal models that addressed the proposed theme and that were published within the stipulated period from March 1, 2013, to March 31, 2023, in English, Portuguese and Spanish. These would later have to go through inclusion stages such as framing the type of study and exclusion criteria.Data Collection: Author's name, year of publication, study population, number of patients, analgesic, administration time, dose, and effect.Conclusions: There are in vitro and in vivo studies that link paracetamol and ibuprofen to endocrine and seminal changes that are harmful to male fertility. However, more clinical research is needed to determine the doses and timing of administration that affect fertility. The effects of aspirin on male fertility are still unclear due to the lack of studies and consistent methodologies. There is not enough research on dipyrone and its relationship with male fertility, requiring more studies in this area.

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“…Among them, the most important is the intervention at the level of the vascular endothelium [ 3 , 4 ], modifying the release and production of mediators and, secondarily, the functions of the receptor systems of signal conducting systems [ 3 , 5 ]. Another direction of influence is the influence on the function of blood platelets responsible for the progression of the disease and its exacerbations [ 6 , 7 , 8 ], as well as the growth of atherosclerotic plaques [ 9 , 10 ]. Cardiovascular diseases (CVD) are responsible for over 4 million deaths annually in Europe [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Inclisiran—Safety and Effectiveness of Small Interfering RNA in Inhibition of PCSK-9

et al. 2023

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Dyslipidemia is listed among important cardiovascular disease risk factors. Treating lipid disorders is difficult, and achieving desirable levels of LDL-cholesterol (LDL-C) is essential in both the secondary and primary prevention of cardiovascular disease. For many years, statins became the basis of lipid-lowering therapy. Nevertheless, these drugs are often insufficient due to their side effects and restrictive criteria for achieving the recommended LDL-C values. Even the addition of other drugs, i.e., ezetimibe, does not help one achieve the target LDL-C. The discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) discovery has triggered intensive research on a new class of protein-based drugs. The protein PCSK9 is located mainly in hepatocytes and is involved in the metabolism of LDL-C. In the beginning, antibodies against the PCSK9 protein, such as evolocumab, were invented. The next step was inclisiran. Inclisiran is a small interfering RNA (siRNA) that inhibits the expression of PCSK9 by binding specifically to the mRNA precursor of PCSK9 protein and causing its degradation. It has been noticed in recent years that siRNA is a powerful tool for biomedical research and drug discovery. The purpose of this work is to summarize the molecular mechanisms, pharmacokinetics, pharmacodynamics of inclisiran and to review the latest research.

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Acetylsalicylic Acid–Primus Inter Pares in Pharmacology

Cited by 11 publications

References 217 publications

The Bioavailability of Drugs—The Current State of Knowledge

The Bioavailability of Drugs—The Current State of Knowledge

Effects of major analgesics on male fertility: A systematic literature review

Inclisiran—Safety and Effectiveness of Small Interfering RNA in Inhibition of PCSK-9

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