Acetylenic Epoxy Fatty Acids

Dembitsky, Valery M.; Kuklev, Dmitry V.

doi:10.1016/b978-0-12-809521-8.00011-8

Cited by 3 publications

(6 citation statements)

References 72 publications

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“…This polyhydroxysteroid showcases unique chemical characteristics and possesses significant biological activity [28]. Additionally, a rare poly-hydroxysteroid, (1α,3β,5β,6β,11α,15α)-5,6-epoxy-gorgostane-1,3,11,15-tetrol (11), was discovered in the extract of the gorgonian Isis hippuris. This compound represents a unique example of a polyhydroxysteroid bearing a 5,6-epoxy group [29].…”

Section: Steroids Bearing a 56-epoxy Groupmentioning

confidence: 99%

“…Research on steroids with a 4,5-epoxy group aims to understand their mechanisms of action, structure–activity relationships, and potential pharmacological applications. By exploring the properties and activities of these compounds, scientists strive to uncover new insights into their roles in health, disease, and therapeutic interventions [ 9 , 10 , 11 , 12 , 13 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Steroids Bearing a 45-epoxy Groupmentioning

confidence: 99%

“…This α,β-epoxy group adds chemical reactivity and contributes to the unique properties and potential biological activities of these compounds. Steroids with an α,β-epoxy group can be found in various natural sources, including fungi, plants, animals, and microorganisms [ 11 , 12 , 13 , 14 , 15 ]. They have also been synthesized in the laboratory for pharmaceutical and research purposes.…”

Section: Introductionmentioning

confidence: 99%

“…Steroids with an α,β-epoxy group can be found in various natural sources, including fungi, plants, animals, and microorganisms [11][12][13][14][15]. They have also been synthesized in the laboratory for pharmaceutical and research purposes.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Steroids Bearing Oxirane Ring

Dembitsky

2023

Biomedicines

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This review explores the biological activity and structural diversity of steroids and related isoprenoid lipids, with a particular focus on compounds containing an oxirane ring. These natural compounds are derived from fungi, fungal endophytes, as well as extracts of plants, algae, and marine invertebrates. To evaluate their biological activity, an extensive examination of refereed literature sources was conducted, including in vivo and in vitro studies and the utilization of the QSAR method. Notable properties observed among these compounds include strong anti-inflammatory, antineoplastic, antiproliferative, anti-hypercholesterolemic, antiparkinsonian, diuretic, anti-eczematic, anti-psoriatic, and various other activities. Throughout this review, 3D graphs illustrating the activity of individual steroids are presented, accompanied by images of selected terrestrial or marine organisms. Furthermore, this review provides explanations for specific types of biological activity associated with these compounds. The data presented in this review are of scientific interest to the academic community and carry practical implications in the fields of pharmacology and medicine. By analyzing the biological activity and structural diversity of steroids and related isoprenoid lipids, this review offers valuable insights that contribute to both theoretical understanding and applied research. This review draws upon data from various authors to compile information on the biological activity of natural steroids containing an oxirane ring.

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Section: Steroids Bearing a 56-epoxy Groupmentioning

confidence: 99%

Section: Steroids Bearing a 45-epoxy Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive Steroids Bearing Oxirane Ring

Dembitsky

2023

Biomedicines

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“…The addition of specific lipases is needed to catalyze the lysis of fatty acids from the triglyceride [26]. Fatty acids are long hydrocarbon chain molecules with a carboxyl-terminal group [27] that can be widely used as versatile intermediates and chemicals in industrial applications such as, among others, cosmetics [28], pharmaceutical manufacturing [29], or surfactants [30].…”

Section: Introductionmentioning

confidence: 99%

A Green Technology Approach Using Enzymatic Hydrolysis to Valorize Meat Waste as a Way to Achieve a Circular Economy

Angulo,

Márquez

2023

Applied Sciences

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The retail meat industry produces a significant amount of waste, containing proteins, lipids, and other elements that could serve as the basis for other products. This work presents the results of research on the enzymatic hydrolysis of meat waste as a green technology to obtain products with added value as a substitute for other raw materials. pH, temperature, the protease/proteinic substrate ratio (Eo/So), and the lipolase/lipidic substrate ratio (Eo’/So’) were studied as process variables for hydrolysis of proteins and lipids, respectively. Hydrolysis for the recovery of proteins (as protein hydrolysates or collagen) was carried out with the protease Alcalase; pH around 8.0, temperature around 50 °C, and Eo/So around 0.16 AU/g were the optimum process variables’ values for obtaining high amounts of recovered proteins and peptides that are easily digestible and have a pleasant taste. The lipase Resinase was used to hydrolyze the lipids; a clear relationship was observed between Eo’/So’ and the amounts of recovered fatty acids. The optimum process variables’ values were found to be Eo’/So’ around 0.83 kLU/g, pH around 8.0 and temperature around 50 °C. Unsaturated fatty acids prevailed in the final product. For the simultaneous recovery of protein hydrolysates, collagen, and fatty acids, a combination of Alcalase and Resinase was used; the process variables examined included the optimal range of values for Eo/So and Eo’/So’, as well as pH and temperature that were suggested in research for both Alcalase and Resinase, separately. The results showed that the simultaneous process was mainly influenced by the Eo/So and Eo’/So’ ratios, instead of being influenced by the pH and temperature values which were less influential. For Eo/So = 0.16 AU/g, Eo’/So’ = 1.11 kLU/g, pH = 7.5, T = 50 °C, the maximum amounts of products (0.8 kg by kg of dry meat waste) were obtained more economically, where the whole of the proteins and lipids in meat waste were practically recovered. Therefore, in order to preserve a circular economy for retail meat waste, enzymatic hydrolysis is appealing and environmentally friendly.

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