Acetylene in Organic Synthesis: Recent Progress and New Uses

Abstract

Recent progress in the leading synthetic applications of acetylene is discussed from the prospect of rapid development and novel opportunities. A diversity of reactions involving the acetylene molecule to carry out vinylation processes, cross-coupling reactions, synthesis of substituted alkynes, preparation of heterocycles and the construction of a number of functionalized molecules with different levels of molecular complexity were recently studied. Of particular importance is the utilization of acetylene in the synthesis of pharmaceutical substances and drugs. The increasing interest in acetylene and its involvement in organic transformations highlights a fascinating renaissance of this simplest alkyne molecule.

Quantum‐chemical models of KOH(KOBut)/DMSO superbasic systems and mechanisms of base‐promoted acetylene reactions

“…Base‐promoted reactions of acetylenes (Scheme ) represent an important field of organic chemistry. These reactions are extremely interesting in terms of synthesis, theory, and commercial prospects …”

Calcium‐Based Sustainable Chemical Technologies for Total Carbon Recycling

“…Of course, simple chemical transformations for calcium carbide production should be avoided from consideration due to CO 2 emissions [Eqs. (20) and (21)]. C apturing CO 2 with one additional equivalent of calcium hydroxide is as uitable option for a better overall transformation [Eq.…”

“…Such sustainable processes can be implemented in a multistep manner because CO and CO 2 released during the synthesis of calcium carbide[ see Scheme 1a nd Eqs. (20) and (21)] can be transformed into carbon materials [71] and reused in the synthesis of calcium carbide. Of course, the direct production of calcium carbidef rom calcium hydroxide or calcium carbonatew ould be the best option, but it is ac hallenging aim to achieve [Eqs.…”

“…Through a sequence of additions, different products can be prepared under simple conditions, potentially without any byproducts (addition reactions are atom economic and free of waste by definition). However, gaseous acetylene is explosive, even if mixed with other gases, and the corresponding laboratory practice is significantly retarded by this circumstance . Recent studies have shown how to develop convenient and practical procedures for acetylene chemistry with the involvement of calcium carbide .…”

“…However,g aseous acetylene is explosive, even if mixed with other gases, [19] and the corresponding laboratory practice is significantly retarded by this circumstance. [20] Recent studies have shown how to develop convenienta nd practical procedures for acetylene chemistry with the involvemento fc alcium carbide. [21] CaC 2 has an umber of advantages over gaseous acetylene.…”