Acetylcysteine In Diabetes (AID): A randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics

Coyle, Louis C.; Rodríguez, Antonio Pérez; Jeschke, Robert E.; Simon-Lee, Anabela; Abbott, Kevin C.; Taylor, Allen J.

doi:10.1016/j.ahj.2006.02.002

Cited by 56 publications

(31 citation statements)

References 15 publications

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“…The incidence of CIN in the control group ranged from 1.5% to 35.3% with an average of 16.9%. CIN was significantly more common in the NAC group in only one of the nine studies, 33 other eight studies provided no significant evidence of a risk reduction for development of CIN with NAC contrast-associated nephropathy.…”

Section: Effects Of Nac On Outcomes In Population With Diabetesmentioning

confidence: 94%

N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis

Kang

et al. 2015

Renal Failure

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(2015) Nacetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis, Renal Failure, 37:10,[297][298][299][300][301][302][303] 2 ¼ 5% for the group of diabetes). Conclusion: Our results suggest that NAC decreases the incidence of contrast-induced nephropathy among patients with pre-existing renal insufficiency. The benefit was not existed in patients with diabetes.

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Section: Effects Of Nac On Outcomes In Population With Diabetesmentioning

confidence: 94%

N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis

Kang

et al. 2015

Renal Failure

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“…39. Leoncini M, Toso A, Maioli M, Tropeano F, Villani S, Bellandi F. Early high-dose 35 36 rosuvastatin for contrast-induced nephropathy prevention in acute coronary syndrome: 37 38 39 Results from the PRATO-ACS Study (Protective Effect of Rosuvastatin and 40 …”

Section: 28mentioning

confidence: 99%

“…Consistent with our results, the TRACK-D 15 16 17 study involving almost 3,000 DM participants with mild-to-moderate CKD 18 19 20 demonstrated a significant reduction in the relative risk of CI-AKI with rosuvastatin 21 22 therapy. 40 …”

mentioning

confidence: 99%

“…Figure S4: Assessment of inconsistency 38 We estimated inconsistency as the difference between direct and indirect estimates 40 (called inconsistency factor, IF) and the corresponding 95% confidence intervals (CI) 41 for IF in each closed loop. The following graphs show all closed triangular loops (loops Table S1 Click here to download Supplementary Figure, Table, or Item (online publication only) Table S1.docx Abbreviations: CI, confidence interval; N, number of trials; n, number of patients; NA, no available; NAC, Nacetylcysteine; OR, odds ratio, vs., versus.…”

mentioning

confidence: 99%

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Comparative Effectiveness of 12 Treatment Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-analysis

Xie

Liu

et al. 2017

American Journal of Kidney Diseases

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“…In patients stratified as high or low risk based on GFR, NAC conferred some benefit when combined with hydration, with multivariate analysis confirming age, volume of contrast, diabetes, and peripheral vascular disease as significant factors for CIN development [232]. However, no benefit was observed in studies using NAC in vascular patients [233,234] nor in diabetic patients when compared with hydration alone [235]. Several recent studies have employed the use of NAC with other agents such as bicarbonate [236,237], hydration, and theophylline, with mixed results [70,151,[237][238][239][240].…”

Section: Rationalementioning

confidence: 92%

Prevention of acute kidney injury and protection of renal function in the intensive care unit

et al. 2009

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Background: Acute renal failure on the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine recommendations for the prevention of acute kidney injury (AKI), focusing on the role of potential preventative maneuvers including volume expansion, diuretics, use of inotropes, vasopressors/vasodilators, hormonal interventions, nutrition, and extracorporeal techniques. Method: A systematic search of the literature was performed for studies using these potential protective agents in adult patients at risk for acute renal failure/kidney injury between 1966 and 2009. The following clinical conditions were considered: major surgery, critical illness, sepsis, shock, and use of potentially nephrotoxic drugs and radiocontrast media. Where possible the following endpoints were extracted: creatinine clearance, glomerular filtration rate, increase in serum creatinine, urine output, and markers of tubular injury. Clinical endpoints included the need for renal replacement therapy, length of stay, and mortality. Studies are graded according to the international Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) group system Conclusions and recommendations: Several measures are recommended, though none carries grade 1A. We recommend prompt resuscitation of the circulation with special attention to providing adequate hydration whilst avoiding high-molecular-weight hydroxy-ethyl starch (HES) preparations, maintaining adequate blood Intensive Care Med (2010) 36:392-411 DOI 10.1007/s00134-009-1678 EXPERT PANEL pressure using vasopressors in vasodilatory shock. We suggest using vasopressors in vasodilatory hypotension, specific vasodilators under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal insufficiency undergoing coronary intervention.

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Acetylcysteine In Diabetes (AID): A randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics

Cited by 56 publications

References 15 publications

N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis

N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis

Comparative Effectiveness of 12 Treatment Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-analysis

Prevention of acute kidney injury and protection of renal function in the intensive care unit

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