Acetylcholinesterase reactivators. Pyridyl and anilyl trifluoromethyl ketoximes

Abstract

67 (1971). (17) Edinburgh Staff, "Pharmacological Experiments on Isolated Preparations," 1st ed, Livingstone, Edinburgh, pp 13-63. (18) G.

Oxime functionality in surfactant self-assembly: An overview on combating toxicity of organophosphates

“…Salvador et al [68] have synthesized 2-, 3-, and 4-trifluoromethyl ketoxime isomers (13) of pyridine and N,N-dimethylaniline. They found that these nucleophiles were quite active in providing protection against either paraoxon or sarin.…”

Solvent Effects on Reactions of Hydroxide and Oximate Ions With Phosphorus(v) Esters

“…19 syn-Benzaldoxime (BAO) (Aldrich) was used as received. ␣,␣,␣-Trifluoroacetophenone oxime (TFAO) was prepared as described by Salvador et al 20 and was an equimolar synanti mixture. 21a 2-Methoxybenzaldoxime (BAO-OMe) was prepared as described 22 and was recrystallized from EtOH, m.p.…”

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

“…Acid dissociation constants for pyridinealdoximes and their methiodides (2-, 3-and 4-PAM) [28][29][30][31][32][33] reflect the inductive and conjugative effect of the nitrogen atom. Reactivating power of inhibited enzyme decreases in the order 2-PAM (pK a 7.8) > 4-PAM (8.5) ) 3-PAM (9.2) [33,34].We measured pK a values and secondorder rate constants (k ox À) towards sarin of the fluorinated pyridine aldoximes and some perprotio analogues (Table 1). A fluorine atom in the 3-position barely affected the pK a of pyridine 2-and 4-aldoxime.…”