Acetylcholinesterase inhibitory properties of some benzoic acid derivatives

Yildiz, Melike; Kılıç, Deryanur; Ünver, Yağmur; Şentürk, Murat; Aşkın, Hakan; Küfrevioğlu, Ömer İrfan

doi:10.1063/1.4945928

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Enzyme AChE metabolizes ACh in the synaptic cleft to acetic acid and choline [55]. On the other hand, AChE activity might lead to a lack of ACh and cognitive deficit [56]. In the current study, SCOP-induced animals improved AChE levels compared to control rats.…”

Section: Discussionmentioning

confidence: 55%

“…Learning and memory are both aided by the central cholinergic system [ 1 ], and ACh is a key neurotransmitter that modulates intellectual performance and learning processes [ 1 , 55 ]. Enzyme AChE metabolizes ACh in the synaptic cleft to acetic acid and choline [ 56 ]. On the other hand, AChE activity might lead to a lack of ACh and cognitive deficit [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

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Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

et al. 2023

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The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats ( n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg −1 ) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg −1 day −1 saline, and all other groups were administered SCOP (1 mg kg −1 day −1 , i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1 β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

et al. 2023

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“…The central cholinergic system is closely related to learning and memory functions [24] and ACh widely scattered in the nervous system is one of the important neurotransmitters and plays a critical role in modulating cognitive performances and learning and memory processes [11,25]. Cholinergic transmission mainly releases ACh from vesicles and transmits ACh to the synaptic cleft where ACh is hydrolyzed by AChE to acetic acid and choline [26]. However, overmuch AChE activity may lead to ACh deficiency and cognitive dysfunction [27,28].…”

Section: Discussionmentioning

confidence: 99%

Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model

Liao

Nai

et al. 2020

Molecules

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For thousands of years, it has been widely believed that walnut is a kind of nut that has benefits for the human body. Walnut oil, accounting for about 70% of walnut, mainly consists of polyunsaturated fatty acids. To investigate the effect of walnut oil on memory impairment in mice, scopolamine (3 mg/kg body weight/d) was used to establish the animal model during Morris Water Maze (MWM) tests. Walnut oil was administrated orally at 10 mL/kg body weight/d for 8 consecutive weeks. The results showed that walnut oil treatment ameliorated the behavior of the memory-impaired mice in the MWM test. Additionally, walnut oil obviously inhibited acetylcholinesterase activity (1.26 ± 0.12 U/mg prot) (p = 0.013) and increased choline acetyltransferase activity (129.75 ± 6.76 U/mg tissue wet weight) in the brains of scopolamine-treated mice (p = 0.024), suggesting that walnut oil could prevent cholinergic function damage in mice brains. Furthermore, walnut oil remarkably prevented the decrease in total superoxide dismutase activity (93.30 ± 5.50 U/mg prot) (p = 0.006) and glutathione content (110.45 ± 17.70 mg/g prot) (p = 0.047) and the increase of malondialdehyde content (13.79 ± 0.96 nmol/mg prot) (p = 0.001) in the brain of scopolamine-treated mice, indicating that walnut oil could inhibit oxidative stress in the brain of mice. Furthermore, walnut oil prevented histological changes of neurons in hippocampal CA1 and CA3 regions induced by scopolamine. These findings indicate that walnut oil could prevent memory impairment in mice, which might be a potential way for the prevention of memory dysfunctions.

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“…Benzoic acid and benzoate ester derivatives are reported for their antibacterial (Friedman et al, 2003), antifungal (Terreaux et al, 2010), anti-inflammatory (Chen et al, 2007) and anti-protozoal (Kashif et al, 2017) activities. In recent years, benzoic acid derivatives have been reported for their inhibitory activities against different enzymes like urease (Rauf et al, 2014), acetylcholinesterase (Yildiz et al, 2016), tyrosinase (Khan et al, 2010) and Trypanosoma cruzi trans-sialidase (TcTS) (Kashif et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities

Arshad

Sheikh

Kazmi

et al. 2018

Bangladesh J Pharmacol

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Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, 1H, 13C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC50 value 22.4 ± 0.45 μM which is nearest to standard thiourea IC50 value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican.Video Clip of Methodology:7 min 59 sec <a href="https://youtube.com/v/PvGTYUxO7-4">Full Screen</a> <a href="https://youtube.com/watch?v=PvGTYUxO7-4">Alternate</a>

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Acetylcholinesterase inhibitory properties of some benzoic acid derivatives

Cited by 5 publications

References 11 publications

Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model

New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities

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