Acetylcholinesterase inhibitors and Gulf War illnesses

Golomb, Beatrice A.

doi:10.1073/pnas.0711986105

Cited by 187 publications

(153 citation statements)

References 64 publications

(60 reference statements)

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“…Blazer et al (1) challenge my PNAS article (2) connecting acetylcholinesterase inhibitor (AChEi) exposure and Gulf War veterans' (GWV) illness (GWI). Their statements are counter to fact.…”

Section: Reply To Blazer Et Al: Flawed Challenges To ''Acetylcholinementioning

confidence: 99%

Reply to Blazer et al. : Flawed challenges to “Acetylcholinesterase inhibitors and Gulf War illnesses”

Golomb¹

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Blazer et al (1) challenge my PNAS article (2) connecting acetylcholinesterase inhibitor (AChEi) exposure and Gulf War veterans' (GWV) illness (GWI). Their statements are counter to fact.…”

Section: Reply To Blazer Et Al: Flawed Challenges To ''Acetylcholinementioning

confidence: 99%

Reply to Blazer et al. : Flawed challenges to “Acetylcholinesterase inhibitors and Gulf War illnesses”

Golomb¹

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…245 from 1990 to 2012, the number of cases of YEL-AD (n = 31) and deaths (n = 12) from YEL-AVD in travelers has exceeded the reports of YF (n = 6) acquired by natural infection. 247 This raised the question whether the risk of vaccination exceeded the benefit in travelers. 246 …”

Section: Yellow Fever 17-d Vaccinementioning

confidence: 99%

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

Johnson¹

2016

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“…There is epidemiological evidence that consumption of an increased number of PB pills was associated with increased risk of Gulf War Illness and severity of symptoms (2,15). We designed a study to examine the effects of PB treatment after exposure times ranging from 4 hours to 7 days, based on a report that of the soldiers that recalled using PB, the majority took PB for less than seven days (16).…”

Section: Technical Objective 1: Establishment Of Gene Expression Profmentioning

confidence: 99%

Applying Genomic and Genetic Tools to Understand and Mitigate Damage from Exposure to Toxins

Myers¹,

Williams²

2013

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe use of pyridostigmine bromide (PB) in the Gulf War of 1991 has been associated with increased incidence and symptom severity of Gulf War Illness. The goal of our research program was to use zebrafish as a model organism to characterize the effects of PB using locomotive/behavioral phenotyping and unbiased, high-throughput techniques, specifically mRNA-seq. Fish treated with PB exhibited perturbed behavioral patterns as indicated by changes in place preference. Exposure to PB altered expression of genes related to the synapse, calcium binding and signaling, cytoskeleton, cell junctions, oxidation-reduction reactions, and regulation of transcription in both larval and adult zebrafish. We studied the impact of genetic background using three strains of zebrafish. We also investigated the effect of stress on the PB response in both larval and adult zebrafish. The study of adult zebrafish allowed for characterization of tissue-specific gene expression in the brain and skeletal muscle, both immediately following PB exposure and at 8 weeks thereafter. These findings provide new insight into the effects of PB at the molecular level, which may aid in the development of therapies for Gulf War Illness. SUBJECT TERMS EXECUTIVE SUMMARYSoldiers of the 1991 Gulf War were given the drug pyridostigmine bromide (PB) for pretreatment against nerve agents. This drug has since been associated with increased incidence and symptom severity of Gulf War Illness. The goal of our research program was to use zebrafish as a model organism for the characterization of the effects of pyridostigmine bromide on gene expression using unbiased, high-throughput techniques, specifically mRNA-seq. Additionally, we intended to study the PB response in the presence of factors that may modulate the effects of PB as indicated by epidemiological and experimental evidence, such as genetic variation or stress. Over the duration of the award, we have successfully characterized phenotypes associated with PB exposure and measured the molecular response using mRNA-seq. We further studied the effects of PB in the context of three different genetic backgrounds and under stressful conditions. Larval zebrafish were utilized to stu...

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Acetylcholinesterase inhibitors and Gulf War illnesses

Cited by 187 publications

References 64 publications

Reply to Blazer et al. : Flawed challenges to “Acetylcholinesterase inhibitors and Gulf War illnesses”

Reply to Blazer et al. : Flawed challenges to “Acetylcholinesterase inhibitors and Gulf War illnesses”

Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

Applying Genomic and Genetic Tools to Understand and Mitigate Damage from Exposure to Toxins

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