Acetylcholinesterase inhibition properties of Hypericum foliosum Aiton

Arruda, Mariana Oliveira; Rainha, Nuno; Barreto, Modesto; Lima, Elaine A. C.; Baptista, José Gregorio

doi:10.1055/s-0030-1264371

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the antioxidant and anti-inflammatory activity of some preparations or isolated compounds is relevant for the treatment of AD, because the increased endogenous formation of free radicals can contribute to the formation of β-amyloid plaques and inflammation [9]. Several studies have showed notable anticholinesterase activity of H. perforatum [10,11,12] and some other Hypericum species extracts [13,14], but the activity have not been supported with the chemical composition or specific compounds identified in samples. However, one study [15] showed that hyperforin could prevent β-amyloid neurotoxicity and spatial memory impairments by disaggregation of β-amyloid deposits.…”

Section: Introductionmentioning

confidence: 99%

“…Some of these species, such as H. venustum [21], H. undulatum and H. androsaemum [10,31,32], and H. rumeliacum [30] have at least been partially chemically characterized. However, there is an increasing interest in the examination of different Hypericum species, especially related to the evaluation of antioxidant, antimicrobial, and recently found anticholinesterase activity [10,14,21,22,23,29,30,31,32,23,29]. Nevertheless, the studies of these species and their activity are often not supported with discovered quantification of the identified constituents [11,12,13,29].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Origin and Biological Source on Chemical Composition, Anticholinesterase and Antioxidant Properties of Some St. John’s Wort Species (Hypericum spp., Hypericaceae) from the Central Balkans

et al. 2013

View full text Add to dashboard Cite

Abstract:The study shows the influence of the origin of plant material and biological source on the in vitro antioxidant (neutralization of DPPH and OH radical, nitric oxide, and inhibition of lipid peroxidation) and anticholinesterase activity of chemically characterized and quantified ethanol extracts of ten St. John's wort samples. The investigated samples were: five Hypericum perforatum species representatives collected at different localities, one commercial sample of Hyperici herba purchased at a local market and four Hypericum species autochtonous to the Balkan Peninsula (H. maculatum subsp. immaculatum, H. olympicum, H. richeri subsp. grisebachii and H. barbatum). All the examined extracts exhibited notable antioxidant potential, but in most of the cases indigenous Hypericum species expressed stronger effects compared to the original source of the drug, H. perforatum. The changes in the content of phenolic compounds, especially flavonoids, hyperforin and hypericin, related to the source of the drug affected the investigated activities. Since all of the investigated species have shown prominent inhibition of

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Origin and Biological Source on Chemical Composition, Anticholinesterase and Antioxidant Properties of Some St. John’s Wort Species (Hypericum spp., Hypericaceae) from the Central Balkans

et al. 2013

View full text Add to dashboard Cite

show abstract

Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum

Özkan

Yilmaz-Ozden

Özsoy

et al. 2018

South African Journal of Botany

View full text Add to dashboard Cite

Hypericum foliosum Quality Botanical and Chemical Markers and In Vitro Antioxidant and Anticancer Activities

Caldeira

Zhang

Gouveia

et al. 2023

Plants

View full text Add to dashboard Cite

Hypericum foliosum Aiton is an endemic Azorean Hypericum species. Even though the aerial parts of Hypericum foliosum are not described in any official pharmacopoeia, they are utilized in local traditional medicine due to their diuretic, hepatoprotective, and antihypertensive properties. This plant has previously been the subject of phytochemical characterization and has been studied for its antidepressant activity, showing significant results in animal models. The lack of a description of the main characteristics of the aerial parts, which would be necessary to properly identify this medicinal plant species, contributes to the possibility of misidentification events. We performed macroscopic and microscopic analyses that identified specific differential characteristics, such as the absence of dark glands, the dimensions of the secretory pockets in the leaf, and the presence of translucent glands in the powder. To continue our previous work on the biological activity of Hypericum foliosum, ethanol, dichloromethane/ethanol, and water extracts were prepared and studied for their antioxidant and cytotoxic activity. Extracts showed in vitro selective cytotoxic activity in human lung cancer cell line A549, colon cancer cell line HCT 8, and breast cancer cell line MDA-MB-231, with dichloromethane/ethanol showing higher activity against all cell lines (IC50 values of 71.49, 27.31, and 9.51 µg/mL, respectively). All extracts also showed significant antioxidant activity.

show abstract

Acetylcholinesterase inhibition properties of Hypericum foliosum Aiton

Cited by 3 publications

References 0 publications

Impact of Origin and Biological Source on Chemical Composition, Anticholinesterase and Antioxidant Properties of Some St. John’s Wort Species (Hypericum spp., Hypericaceae) from the Central Balkans

Impact of Origin and Biological Source on Chemical Composition, Anticholinesterase and Antioxidant Properties of Some St. John’s Wort Species (Hypericum spp., Hypericaceae) from the Central Balkans

Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum

Hypericum foliosum Quality Botanical and Chemical Markers and In Vitro Antioxidant and Anticancer Activities

Contact Info

Product

Resources

About