Acetylcholinesterase in Thrombocytes

Cytoplasmic Nucleotides in the Megakaryocytes

“…Recently, results from studies of the acetylcholineesterase enzyme in megakaryocytes and platelets from different species have provided a chemical support of Wright's theory (1,(14)(15)(16)) as compared to the earlier evidences which are largely structural and tinctorial.…”

Experimental Approaches to the Biologic Action of Ultraviolet Rays

“…It is of interest to note that whereas the same results were obtained in Rana esculenta and Rana temporaria with anticholinesterase tetraethylpyrophosphate, only the former amphibian responded to atropine. This enzyme and these drugs influence acetylcholine metabolism which in its turn, as shown by ROTHENBERG and by HOLLAND, DUNN and GRIEG, modified ion movement in a variety of tissues; the presence of acetylcholinesterase was demonstrated (1) in the thrombocytes and erythrocytes of different animal species. If this is true for the frog, the destruction of the enzyme by ultraviolet light might be considered feasible.…”

Cholinesterase inactivation by snake venoms

“…Additional evidence for such a possibility is presented in the present work. Thus substances which stabilize the cholinesterase of cobra venom, such as metal ions (Augustinsson & Grahn, 1952), gelatin, gum acacia and albumin (Mounter, 1951), were shown to protect the cholinesterase from destruction by the Najavenom anticholinesterase. Moreover, the order of the potency for the inhibition of anticholinesterase Table 9.…”

“…and the Department of Phy8iology and Pharmacology, Graduate School of Medicine, Univeraity of Penn8ylvania, Philadelphia, Penn8ylvania, U.S.A. (Received 23 July 1955) Although the instability of the cholinesterase of cobra venom in aqueous solution has been pointed out by previous authors (Mounter, 1951;Augustinsson & Grahn, 1952), its cause is unknown. During studies of the cholinesterase of Formosan snake venoms, a high potency of cholinesterase inactivation (anticholinesterase) was found in the cholinesterase-containing venom of the Formosan cobra (Naja naja atra) (Chang & Lee, 1955).…”