Acetylcholinesterase-functionalized two-dimensional photonic crystals for the detection of organophosphates

Qi, Fenglian; Lan, Yunhe; Meng, Zihui; Cao, Yan; Li, Shuguang; Xue, Min; Wang, Yifei; He, Xuan; Liu, Xueyong

doi:10.1039/c8ra04953j

Cited by 17 publications

(9 citation statements)

References 34 publications

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“…The clear advantage of this approach is that one can even avoid using a spectrometer; a laser diode, a precise ruler, and the naked eye or a simple camera are sufficient. Qi et al [43] developed a portable device for the detection of Dipterex, an organophosphate pesticide, based on a 2D PhC fabricated starting from 600 nm polystyrene colloidal particles embedded into a polyacrylamide-acrylic acid hydrogel, and achieved a LOD of 7.7 × 10 −12 mmol/L. As another example, Lan et al [44], still using polystyrene particles but embedding them into a 3acrylamidophenylboronic acid functionalized hydrogel, were able to realize a PhC sensor for glucose monitoring in urine.…”

Section: Photonic Crystals For Chemical Sensingmentioning

confidence: 99%

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

et al. 2020

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Photonic crystals (PhC) are spatially ordered structures with lattice parameters comparable to the wavelength of propagating light. Their geometrical and refractive index features lead to an energy band structure for photons, which may allow or forbid the propagation of electromagnetic waves in a limited frequency range. These unique properties have attracted much attention for both theoretical and applied research. Devices such as high-reflection omnidirectional mirrors, low-loss waveguides, and high- and low-reflection coatings have been demonstrated, and several application areas have been explored, from optical communications and color displays to energy harvest and sensors. In this latter area, photonic crystal fibers (PCF) have proven to be very suitable for the development of highly performing sensors, but one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) PhCs have been successfully employed, too. The working principle of most PhC sensors is based on the fact that any physical phenomenon which affects the periodicity and the refractive index of the PhC structure induces changes in the intensity and spectral characteristics of the reflected, transmitted or diffracted light; thus, optical measurements allow one to sense, for instance, temperature, pressure, strain, chemical parameters, like pH and ionic strength, and the presence of chemical or biological elements. In the present article, after a brief general introduction, we present a review of the state of the art of PhC sensors, with particular reference to our own results in the field of mechanochromic sensors. We believe that PhC sensors based on changes of structural color and mechanochromic effect are able to provide a promising, technologically simple, low-cost platform for further developing devices and functionalities.

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Section: Photonic Crystals For Chemical Sensingmentioning

confidence: 99%

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

et al. 2020

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“…They have been the most distinguished chemical warfare agents amongst the gaseous nerve agents. Their excessive toxicity, cheapness and simple manufacturing make them a significant concern for both of civilians and governments, particularly for war associated conflicts [1–5] . Organophosphonate‐based nerve agents are organophosphorous derivatives bearing a good leaving group as shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

2021

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Synthesis and spectroscopic characterization of a low molecular mass organogelator based on alkyl chain‐substituted tricyanofuran hydrazone (TCFH) dyes are described for detecting organophosphorus based nerve agent mimic. The reactivity of the prepared TCFH‐based organogel towards diethylchlorophosphonate (DCP) has been examined in organic phases. TCFH chromophore showed a successful gelation ability of different organic solvents. In addition, responsiveness of TCFH to nerve agent mimic with a gel‐sol reversible switching was monitored associated with colorimetric shifting from yellow to blue. The supramolecular self‐assembly of TCFH occurs via van der Waals interactions as well as cooperative π‐π stacking leading to gel formation in organic solvents. Moreover, the existence of nerve agents‐based gases results in a remarkable variation in the rheological behavior of the tricyanofuran hydrazone‐based gel. Scanning electron microscopy (SEM) images demonstrated that the xerogel generated from n‐propanol (n‐PrOH) is able to create fibrous supramolecular architecture with the ability for naked‐eye detection of a nerve agent mimic. The development of TCFH‐based supramolecular organogel in organic solvents was disturbed by the nerve agent mimic presenting a novel detection technique for organophosphorus warfare agents.

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“…The use of both natural and synthetic PhCs as vapor sensors has been widely explored over the last twenty years [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23], though relatively few studies have examined their viability as CWA simulant detectors [24][25][26][27][28][29][30][31][32]. Typically, these studies have involved synthetic PhCs composed of porous silicon.…”

Section: Introductionmentioning

confidence: 99%

“…Porous silicon PhCs without selective features (e.g., no functionalization) have detected the presence of CWA simulants via shifts in reflectance spectra with sensitivity as low as 4 ppm [27], though signatures were not unique and were a function of refractive index and concentration of the analyte vapor [27,28]. To introduce a degree of selectivity towards CWA simulants, porous silicon sensors have been fabricated with coatings containing functional groups reactive to CWAs and CWA simulants [25,26,29,30,32]. Generally, interaction of the CWA or CWA simulant with the coating caused a change in the thickness of the coating and thus the periodic spacing of the PhC, resulting in a detectable response that was restricted to analytes that react with the coating.…”

Section: Introductionmentioning

confidence: 99%

Vapor Selectivity of a Natural Photonic Crystal to Binary and Tertiary Mixtures Containing Chemical Warfare Agent Simulants

Kittle

Fisher

Kunselman

et al. 2019

Sensors

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Vapor sensing via light reflected from photonic crystals has been increasingly studied as a means to rapidly identify analytes, though few studies have characterized vapor mixtures or chemical warfare agent simulants via this technique. In this work, light reflected from the natural photonic crystals found within the wing scales of the Morpho didius butterfly was analyzed after exposure to binary and tertiary mixtures containing dimethyl methylphosphonate, a nerve agent simulant, and dichloropentane, a mustard gas simulant. Distinguishable spectra were generated with concentrations tested as low as 30 ppm and 60 ppm for dimethyl methylphosphonate and dichloropentane, respectively. Individual vapors, as well as mixtures, yielded unique responses over a range of concentrations, though the response of binary and tertiary mixtures was not always found to be additive. Thus, while selective and sensitive to vapor mixtures containing chemical warfare agent simulants, this technique presents challenges to identifying these simulants at a sensitivity level appropriate for their toxicity.

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Acetylcholinesterase-functionalized two-dimensional photonic crystals for the detection of organophosphates

Abstract: AChE-modified 2D-PC was developed for the easy and visual detection of organophosphates.

Cited by 17 publications

References 34 publications

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

Vapor Selectivity of a Natural Photonic Crystal to Binary and Tertiary Mixtures Containing Chemical Warfare Agent Simulants

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