Acetylcholinesterase and human cancers

Richbart, Stephen D.; Merritt, Justin C.; Nolan, Nicholas; Dasgupta, Piyali

doi:10.1016/bs.acr.2021.05.001

Cited by 22 publications

(16 citation statements)

References 188 publications

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“…Casein kinase 1 members are involved in a variety of cellular growth and survival processes, including circadian rhythms and DNA repair. Besides its role in synaptic transmission, ACHE also regulates multiple oncogenic signaling pathways involved in the classic function of tumors, including proliferation, invasion, and metastasis [ 55 ]. A study by Tan et al showed that SRT1720 inhibits bladder cancer growth by inhibiting the SIRT1-HIF pathway [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma

Jiang

Cai

Yang

et al. 2023

Oxidative Medicine and Cellular Longevity

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Rationale. Recent research has suggested that melatonin-related regulators play crucial roles in solid cancers and may be new targets for cancers. However, the characteristics and roles of melatonin modulators in clear cell renal cell carcinoma (ccRCC) remain largely unknown. Methods. Adopting multiomics data from TCGA and other public datasets, we analysed the expression, mutation, and prognostic evaluation in multiple cancers. ccRCC patients were categorized into two subgroups by an unsupervised cluster algorithm: melatonin-pattern cancer subtype 1 (MPCS1) and subtype 2 (MPCS2). We then explored the immune microenvironment, immune therapy response, and tumor metabolic pathways between the two subtypes. The clinical characteristics, genomic mutation landscape, and molecular inhibitor response were further investigated. Finally, a melatonin regulator-related prognostic model was constructed to predict patient prognosis in ccRCC. Results. We found that melatonin regulators were dysregulated depending on distinct cancer types, which were associated with genomic variation. The two subtypes indicated different clinical characteristics and biological processes in ccRCC. MPCS2, an aggressive subtype, led an advanced clinical stage and poorer survival of ccRCC patients. The activated oncogenic signaling pathway and metabolic signatures were responsible for cancer progression in the MPCS2 subtype. The MPCS2 subgroup suggested a higher tumor mutational burden and immune dysfunction state, resulting in a lower response to immunotherapy. The copy number variations of MPCS2 were significantly more frequent than those of MPCS1. In addition, the two subgroups exhibited distinct drug responsiveness, with MPCS2 being less responsive to multiple drugs. Finally, we established a subtype biomarker-based prognostic risk model that exhibited satisfactory performance in ccRCC patients. Conclusion. Melatonin regulator-related features could remodel functional pathways and the tumor immune microenvironment through genomic mutations and pathway regulation. Melatonin regulator-associated molecular subtypes enhance the understanding of the molecular characteristics of renal cancer and can guide clinical treatment. Activating the melatonergic system axis may improve the effect of immunotherapy for ccRCC.

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Section: Discussionmentioning

confidence: 99%

Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma

Jiang

Cai

Yang

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…Acetylcholinesterase (AChE) is a key enzyme of the cholinergic nervous system. It is a serine hydrolase whose primary function is to stop neurotransmission by degrading acetylcholine [ 287 , 288 ]. Other non-neuronal functions are attributed to this enzyme, such as involvement in cell growth, apoptosis, drug resistance pathways, response to stress signals, and inflammation [ 288 ].…”

Section: Thymus Algeriensis Boiss and Reutmentioning

confidence: 99%

“…It is a serine hydrolase whose primary function is to stop neurotransmission by degrading acetylcholine [ 287 , 288 ]. Other non-neuronal functions are attributed to this enzyme, such as involvement in cell growth, apoptosis, drug resistance pathways, response to stress signals, and inflammation [ 288 ]. During the development of Alzheimer’s disease, cholinergic neurons in the forebrain become particularly vulnerable.…”

Section: Thymus Algeriensis Boiss and Reutmentioning

confidence: 99%

Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects

Lahlou

Samba

Soeiro

et al. 2022

Foods

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Members of the Lamiaceae family are considered chief sources of bioactive therapeutic agents. They are important ornamental, medicinal, and aromatic plants, many of which are used in traditional and modern medicine and in the food, cosmetic, and pharmaceutical industries. In North Africa, on the Mediterranean side, there is the following particularly interesting Lamiaceous species: Thymus hirtus Willd. sp. Algeriensis Boiss. Et Reut. The populations of this endemic plant are distributed from the subhumid to the lower arid zone and are mainly employed as ethnomedicinal remedies in the following Maghreb countries: Algeria, Libya, Morocco, and Tunisia. In fact, they have been applied as antimicrobial agents, antispasmodics, astringents, expectorants, and preservatives for several food products. The species is commonly consumed as a tea or infusion and is used against hypercholesterolemia, diabetes, respiratory ailments, heart disease, and food poisoning. These medicinal uses are related to constituents with many biological characteristics, including antimicrobial, antioxidant, anticancer, anti-ulcer, anti-diabetic, insecticidal, and anti-inflammatory activities. This review aims to present an overview of the botanical characteristics and geographical distribution of Thymus algeriensis Boiss. Et Reut and its traditional uses. This manuscript also examines the phytochemical profile and its correlation with biological activities revealed by in vitro and in vivo studies.

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“…To assess anticholinesterase activity, all ten compounds (2a-2j) were tested on the enzymes AChE and BuChE. In a previous study, blocking acetylcholinesterase (AChE) reduced cell proliferation in lung carcinoma cell lines [24][25][26][27][28]. It has also been observed that antiproliferation is associated with mitochondrial potential loss and apoptosis.…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

“…All of these factors suggest that the final compounds may have potential against AD. In fact, it was found that acetylcholinesterase (AChE) enzyme inhibition decreased cell growth in lung tumor cell lines in the literature [24][25][26][27][28]. Thus, it can be concluded that for antiproliferation activity, there is a link between mitochondrial potential loss and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives

Nuha

Evren

Çiyanci

et al. 2022

Cumhuriyet Science Journal

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The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.

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Acetylcholinesterase and human cancers

Cited by 22 publications

References 188 publications

Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma

Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma

Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects

Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives

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