Acetylcholinesterase Activity and Neurodevelopment in Boys and Girls

Suárez-López, José R.; Himes, John H.; Jacobs, David R.; Alexander, Bruce H.; Gunnar, Megan R.

doi:10.1542/peds.2013-0108

Cited by 43 publications

(48 citation statements)

References 42 publications

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“…The variation in impulsivity and depression levels may be caused by OPs exposure dose dependently; this could be established by studies on larger populations. In our study no significant association between low AChE activity and gender was found, but gender interaction was reported with OPs exposure in several studies [27,30,31]. Low AChE activity was related with deficits in neurodevelopment, particularly in attention, inhibition, and memory in boys but not in girls [27].…”

Section: Discussioncontrasting

confidence: 71%

“…In our study no significant association between low AChE activity and gender was found, but gender interaction was reported with OPs exposure in several studies [27,30,31]. Low AChE activity was related with deficits in neurodevelopment, particularly in attention, inhibition, and memory in boys but not in girls [27]. Prenatally organophosphate exposed children had greater decreases in attention among boys versus girls in agricultural areas in California [30] and in working memory among children in New York City [31].…”

Section: Discussioncontrasting

confidence: 65%

“…In communities where pesticides were used and stored; high levels of urine metabolites were determined in children [26]; and the association of urinary OPs metabolites and attention deficit hyperactivity disorder was found also [9]. In addition low AChE activity has been associated with deficits in neurodevelopment, particularly in attention, inhibitory control and memory [27].…”

Section: Discussionmentioning

confidence: 99%

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The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

et al. 2016

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Long-term exposure to organophosphate pesticides (OPs) without acute poisoning can lead to various OPs. Environmental exposure to organophosphate pesticides may be associated with depression and suicide attempts in a population living in a rural agricultural area. Patients (n = 149) suffering from major depressive disorder (with and without attempted suicide) and a control group of healthy individuals (n = 64) who had been living in the same rural district for at least 1 year were selected. Red blood cell acetylcholine esterase (RBC-AChE) activity was examined as the basis of evaluating the degree of chronic environmental exposure to OPs residues. There were negative association between RBC-AChE activity levels and suicide attempts, the number of past suicide attempts and hopelessness levels in the depressive patients.The results of the study may support the idea that environmental exposure to OPs may be associated with mental health in individuals living in agricultural districts who are not farmers or working in occupations with access to OPs.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

et al. 2016

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“…Another study found that lower erythrocytic AChE activity in children ages 4–9 was associated with poorer neurodevelopment in boys, but not girls, particularly in attention, inhibition, and memory [100]. Neurodevelopment was measured using the NEPSY-II, an assessment that measures various developmental and NEuroPSYchological domains.…”

Section: Sex-specific Effects Of Childhood Op Exposurementioning

confidence: 99%

Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course

Comfort

Ré

2017

Curr Envir Health Rpt

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Purpose of Review This review discusses the sex-specific effects of exposure to various organophosphate (OP) pesticides throughout the life course and potential reasons for the differential vulnerabilities observed across sexes. Recent findings Sex is a crucial factor in the response to toxicants yet the sex-specific effects of OP exposure, particularly in juveniles and adults, remain unresolved. This is largely due to study design and inconsistencies in exposure and outcome assessments. Summary Exposure to OPs results in multiple adverse outcomes influenced by many factors including sex. Reported sex-specific effects suggest that males are more susceptible to OPs, which reflects the sex-dependent prevalence of various neurodevelopmental and neurodegenerative disorders such as autism and amyotrophic lateral sclerosis (ALS), in which males are at greater risk. Thus, this review proposes that the biological sex-specific effects elicited by OP exposure may in part underlie the dimorphic susceptibilities observed in neurological disorders. Understanding the immediate and long-term effects of OP exposure across sexes will be critical in advancing our understanding of OP-induced neurotoxicity and disease.

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“…This study demonstrated a relationship between acute occupational poisoning with organophosphates and psychological distress, including suicidal thoughts. SUAREZ-LOPEZ et al (2013) found lower Acetylcholinesterase activity associated with lower performance on attention, inhibitory control, and memory in boys in Ecuador. These are critical cognitive skills that affect learning and academic performance.…”

Section: Rural Workers' Health and The Use Of Pesticides In Developinmentioning

confidence: 77%

Rural workers` health related to the use of pesticides in developing and developed countries

Coelho

2017

Revista Vértices

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This review aims to examine the issue rural workers' health and the use of pesticides in its various aspects, especially emphasizing how that is doing in developing and developed countries. We found than the rural workers pesticide contamination problems occur both in developing countries as in developed countries. We concluded than to ensure the rural workers' health when they use pesticides becomes necessary to increase the training of workers. It is also important to build political agendas and actions in the health of agricultural workers, with implementation of preventive health programs with greater oversight and monitoring on pesticide use. IntroductionThe indiscriminate application of pesticides affects both human health and natural ecosystems. The use of pesticides in agriculture can be justified by the need to increase agricultural production, but behind the use of these substances are the risks of occupational diseases confirmed by studies that focus primarily on specific types of substances (SILVA & SADI, 2006). The epidemiology of the use of pesticides in agriculture should be seen not only in terms of consumers, but in view of occupational hazard among farmers or rural workers. DOI: 10.19180/1809DOI: 10.19180/ -2667 In general, there is a false thought that in the developed countries there is no problem related to poisoning of farm workers by pesticides. According to the "Centers for Disease Artigo de RevisãoControl and Prevention" of the United States, agriculture is the most dangerous industry for American workers, affecting mainly the younger ones. It was found that 76% of agricultural workers suffered fatal accident were under 16 years and worked in an agricultural family business that was exempt from child labor laws (CENTERS FOR DISEASE CONTROL AND PREVENTION. NIOSH, 2003).Pesticides have been widely used to control pests and diseases related to agriculture, fisheries, forestry and food industry. Throughout history it was necessary to create laws that establish safety rules regarding the use of pesticides in order to reduce their impact on the environment and the health of farm workers. Leaflet and label are examples of this and are the main sources of information for rural workers, helping to prevent accidents and consequently poisoning (ZAMBRONE & CORREA, 2008).This review aims to examine the issue rural workers' health and the use of pesticides in its various aspects, especially emphasizing how that is doing in developing and developed countries. MetodologyWe utilized the site periodic capes (www.periodicos.capes.gov.br) and the key words utilized were: "segurança and agrotóxico" and "rural work and pesticide". The time was the last 10 years. We found 75 citations and selected 35 than talked about rural workers` health related to the use of pesticides. These 35 citations, 14 were in Portuguese language: 11 papers, 1 dissertation, 1 book and 1 technical bulletin and 21 were in English language: 18 papers, 2 books and 1 technical bulletin. We found mainly citations of the last five years (...

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Acetylcholinesterase Activity and Neurodevelopment in Boys and Girls

Cited by 43 publications

References 42 publications

The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course

Rural workers` health related to the use of pesticides in developing and developed countries

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