Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis

Nitenson, Arielle Schilit; Manzano-Nieves, Gabriela; Poeta, Devon L.; Bahar, Ryan; Rachofsky, Carolyn; Mandairon, Nathalie; Bath, Kevin G.

doi:10.1016/j.isci.2019.11.016

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…Other examples are neuropeptides like prolactin from the pituitary gland during pregnancy (Shingo et al 2003) or β-endorphin from hypothalamic neurons in hunger and satiety (Paul et al 2017). Taken together neuromodulatory changes in neurogenesis will be of great interest in the future, especially since a recent paper demonstrated that cholinergic effects on olfactory learning require adult neurogenesis (Schilit Nitenson et al 2019).…”

Section: Open Questions Concerning Neuromodulation In the Olfactory Bulbmentioning

confidence: 99%

Extrinsic neuromodulation in the rodent olfactory bulb

Brunert

Rothermel

2020

Cell Tissue Res

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Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual’s health and survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to heavily process sensory information. To adapt to an animal’s needs, OB activity can be influenced by many factors either from within (intrinsic neuromodulation) or outside (extrinsic neuromodulation) the OB which include neurotransmitters, neuromodulators, hormones, and neuropeptides. Extrinsic sources seem to be of special importance as the OB receives massive efferent input from numerous brain centers even outweighing the sensory input from the nose. Here, we review neuromodulatory processes in the rodent OB from such extrinsic sources. We will discuss extrinsic neuromodulation according to points of origin, receptors involved, affected circuits, and changes in behavior. In the end, we give a brief outlook on potential future directions in research on neuromodulation in the OB.

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Section: Open Questions Concerning Neuromodulation In the Olfactory Bulbmentioning

confidence: 99%

Extrinsic neuromodulation in the rodent olfactory bulb

Brunert

Rothermel

2020

Cell Tissue Res

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“…In this study, discrimination ability was assessed by distinguishing between similar odor pairs (mainly enantiomer substances), according to previous studies [ 17 , 18 ]. Animal experiments using rats and mice revealed that olfactory discrimination ability was increased by administration of physostigmine, an acetylcholine esterase inhibitor or by the optogenetic stimulation of basal forebrain cholinergic neurons projecting to the olfactory bulb [ 36 , 37 ]. During the discrimination task, basal forebrain cholinergic neurons are recruited [ 38 ] and extracellular acetylcholine releases in the neocortex and hippocampus are increased [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Olfactory function and discrimination ability in the elderly: a pilot study

et al. 2022

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We recently reported that subjects with a higher olfactory identification threshold for rose odor declined more in attentional ability in the elderly. This study focuses on discrimination ability and olfactory identification threshold in twelve elderly subjects living in a community (age: 80.9 ± 1.6). Olfactory function was assessed by the rose odor identification threshold. We assessed the discrimination ability by distinguishing 5 similar odor pairs. Our results showed that the subjects with a higher olfactory identification threshold (≥ 5) declined more in discrimination ability (14% ± 14%, p = 0.03) compared to those with a lower threshold (≤ 4) (averaged value set at 100%). As discrimination ability is related to the basal forebrain cholinergic system, our results suggest that olfactory impairment links to the decline in cognitive function relating the cholinergic system.

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“…From the process of neurogenesis and synaptogenesis, both the synthesis and the activity of neurotransmitters that can be involved in cellular signaling, differentiation, immune response, and cellular migration play an important role 21,22 . This model is applicable to the development of the visual system where, in addition to the role played by growth factors like the factor derived from the brain and the nervous growth factor, among others, neurotransmitters contribute to modulating the visual signal in the early ages of development 23 .…”

Section: Cholinergic Activity In the Visual Pathwaymentioning

confidence: 99%

Cholinergic system and the role it plays in the visual system

Durán-Cristiano¹

2022

RMOE

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The nervous system receives and processes information from the environment thanks to its constant interaction with sensory organs, including vision, a system that includes ocular structures, cortical, and subcortical areas. Consequently, some mediators can receive and transmit visual information so it can be properly processed and interpreted. Among them, the activity of chemical substances called neurotransmitters really stands out, acetylcholine (Ach) in particular since it plays a significant role. Ach acts as a neuromodulator and is involved in the biological events of the visual system that regulate visual functions such as contrast sensitivity, visual perception, and ocular functions like tear production to maintain the homeostasis of the ocular surface. This happens through the interaction of cholinergic receptors on structures of the anterior and posterior segments of the eye. Therefore, the objective of the article is to describe the different aspects that relate to cholinergic activity, the visual system, and its association with the disease.

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Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis

Cited by 10 publications

References 42 publications

Extrinsic neuromodulation in the rodent olfactory bulb

Extrinsic neuromodulation in the rodent olfactory bulb

Olfactory function and discrimination ability in the elderly: a pilot study

Cholinergic system and the role it plays in the visual system

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