Acetylcholine Muscarinic Receptors in Ventral Hippocampus Modulate Stress-Induced Anxiety-Like Behaviors in Mice

Mei, Li; Zhou, Yu; Sun, Yi; Liu, Hong; Zhang, Dengwen; Li, Pingping; Shu, Haihua

doi:10.3389/fnmol.2020.598811

Cited by 22 publications

(14 citation statements)

References 44 publications

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“…Under urethane, FG-7142 induces the release of acetylcholine in the vHPC [100], an effect that was recently found under chronic restraint stress, which is a model of anxiety [101].…”

Section: Drug Administrationmentioning

confidence: 63%

The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

et al. 2021

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Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala–hippocampal–prefrontal network, playing different roles in the ventral and dorsal hippocampi. Deep brain stimulation of the infralimbic cortex in rodents or the human equivalent—the subgenual cingulate cortex—constitutes a fast antidepressant treatment. The aim of this work was: (1) to describe the oscillatory profile in a rodent model of anxiety, and (2) to deepen the therapeutic basis of infralimbic deep brain stimulation in mood disorders. First, the anxiogenic drug FG-7142 was administered to anaesthetized rats to characterize neural oscillations within the amygdala and the dorsoventral axis of the hippocampus. Next, deep brain stimulation was applied. FG-7142 administration drastically reduced the slow waves, increasing delta, low theta, and beta oscillations in the network. Moreover, FG-7142 altered communication in these bands in selective subnetworks. Deep brain stimulation of the infralimbic cortex reversed most of these FG-7142 effects. Cross-frequency coupling was also inversely modified by FG-7142 and by deep brain stimulation. Our study demonstrates that the hyperactivated amygdala–hippocampal network associated with the anxiogenic drug exhibits an oscillatory fingerprint. The study contributes to comprehending the neurobiological basis of anxiety and the effects of infralimbic deep brain stimulation.

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“…Under urethane, FG-7142 induces the release of acetylcholine in the vHPC [100], an effect that was recently found under chronic restraint stress, which is a model of anxiety [101].…”

Section: Drug Administrationmentioning

confidence: 63%

The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

et al. 2021

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“…ACh plays an important role in anxiety. For example, muscarinic receptors of the ventral hippocampus are involved in the induction of anxiety and their activation promotes social avoidance [ 84 ]. In the amygdala, ACh may regulate fear learning and extinction of fear anxiety-like behavior [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of social behavior in young and middle-aged ChAT-IRES-Cre mouse

Lhopitallier

Perrault

Chauveau³

et al. 2022

PLoS ONE

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The cholinergic system is an important modulator of brain processes. It contributes to the regulation of several cognitive functions and emotional states, hence altering behaviors. Previous works showed that cholinergic (nicotinic) receptors of the prefrontal cortex are needed for adapted social behaviors. However, these data were obtained in mutant mice that also present alterations of several neurotransmitter systems, in addition to the cholinergic system. ChAT-IRES-Cre mice, that express the Cre recombinase specifically in cholinergic neurons, are useful tools to investigate the role of the cholinergic circuits in behavior. However, their own behavioral phenotype has not yet been fully characterized, in particular social behavior. In addition, the consequences of aging on the cholinergic system of ChAT-IRES-Cre mice has never been studied, despite the fact that aging is known to compromise the cholinergic system efficiency. The aim of the current study was thus to characterize the social phenotype of ChAT-IRES-Cre mice both at young (2–3 months) and middle (10–11 months) ages. Our results reveal an alteration of the cholinergic system, evidenced by a decrease of ChAT, CHT and VAChT gene expression in the striatum of the mice, that was accompanied by mild social disturbances and a tendency towards anxiety. Aging decreased social dominance, without being amplified by the cholinergic alterations. Altogether, this study shows that ChAT-IRES-Cre mice are useful models for studying the cholinergic system‘s role in social behavior using appropriate modulating technics (optogenetic or DREADD).

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“…Fos immunohistochemistry shows stronger enrolment of vHip in innate anxiety in male mice. 90 This anxiety‐like behaviour was shown to be specifically associated with the activation of vCA1 among other subregions in the vHip. 17 …”

Section: Vca1 and The Effect On Anxietymentioning

confidence: 94%

The complexity of ventral CA1 and its multiple functionalities

Hong

Kaang

2022

Genes Brain and Behavior

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The hippocampus is one of the most widely investigated brain regions with its massive contributions to multiple behaviours. Especially, the hippocampus is subdivided into the dorsal and ventral parts playing distinct roles. In this review, we will focus on the ventral hippocampus, especially the ventral CA1 (vCA1), whose role is being actively discovered. vCA1 is well known to be associated with emotion-like behaviour, in both positive (reward) and negative (aversive) stimuli. How can this small region in volume mediate such variety of responses? This question will be answered with technologies up to date that have allowed us to study in-depth the specific neural circuit and to map the complex connectivity.

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Acetylcholine Muscarinic Receptors in Ventral Hippocampus Modulate Stress-Induced Anxiety-Like Behaviors in Mice

Cited by 22 publications

References 44 publications

The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

Characterization of social behavior in young and middle-aged ChAT-IRES-Cre mouse

The complexity of ventral CA1 and its multiple functionalities

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