2023
DOI: 10.3390/microorganisms11030769
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Acetylcholine Esterase Inhibitory Effect, Antimicrobial, Antioxidant, Metabolomic Profiling, and an In Silico Study of Non-Polar Extract of The Halotolerant Marine Fungus Penicillium chrysogenum MZ945518

Abstract: Major health issues, such as the rise in oxidative stress, incidences of Alzheimer’s disease, and infections caused by antibiotic-resistant microbes, have prompted researchers to look for new therapeutics. Microbial extracts are still a good source of novel compounds for biotechnological use. The objective of the current work was to investigate marine fungal bioactive compounds with potential antibacterial, antioxidant, and acetylcholinesterase inhibitory effects. Penicillium chrysogenum strain MZ945518 was is… Show more

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Cited by 4 publications
(1 citation statement)
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“…The GCMS analysis revealed that the CFEA contains numerous phytochemicals with beneficial biological effects. Some of these substances have been identified as having antimicrobial, antioxidant, and anti-inflammatory properties, including hexanoic acid, 2-ethyl anhydride, n-Hexadecanoic acid ( Thakur et al, 2018 ), glycerol 1,2-diacetate, Hexadecanoic acid ( El-Sayed et al, 2023 ), 1,2,3-Propanetriol, 1-acetate, benzofuran, 2,3-dihydro- ( Rani et al, 2023 ), 3-hydroxy-methyl ester ( Kumar et al, 2021 ), isopropyl hexacosyl ether, and 5-Hydroxymethyl-2-furaldehyde ( Fitriaturosidah et al, 2022 ). Additionally, phenol, 2,4-bis (1,1-dimethyl ethyl)-, has been found to have antifungal and biofilm-rupturing capabilities ( Sharaf, 2020 ), while D-Glucitol, 1,4-anhydro-, has antiophidic effects ( Singh et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…The GCMS analysis revealed that the CFEA contains numerous phytochemicals with beneficial biological effects. Some of these substances have been identified as having antimicrobial, antioxidant, and anti-inflammatory properties, including hexanoic acid, 2-ethyl anhydride, n-Hexadecanoic acid ( Thakur et al, 2018 ), glycerol 1,2-diacetate, Hexadecanoic acid ( El-Sayed et al, 2023 ), 1,2,3-Propanetriol, 1-acetate, benzofuran, 2,3-dihydro- ( Rani et al, 2023 ), 3-hydroxy-methyl ester ( Kumar et al, 2021 ), isopropyl hexacosyl ether, and 5-Hydroxymethyl-2-furaldehyde ( Fitriaturosidah et al, 2022 ). Additionally, phenol, 2,4-bis (1,1-dimethyl ethyl)-, has been found to have antifungal and biofilm-rupturing capabilities ( Sharaf, 2020 ), while D-Glucitol, 1,4-anhydro-, has antiophidic effects ( Singh et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%