Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas

Hokin-Neaverson, Mabel

doi:10.1016/s0006-291x(74)80483-3

Cited by 107 publications

(32 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This possibility appears to be particularly attractive in that a hydrolysis of phosphoinositides has been observed in other tissues after hormonal or metabolic activation (7)(8)(9)(10)(11)(12). The MI released by the renal cell could arise directly from the cell membranes or by raising the concentration ofintracellular MI.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Glucose and Parathyroid Hormone on the Renal Handling of Myoinositol by Isolated Perfused Dog Kidneys

Molitoris¹,

Hruska

Fishman

et al. 1979

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The effects of glucose and parathyroid hormone (PTH) on the transport and metabolism of myoinositol (MI) and [2-3H] 1110 release were about coincidental with the increase in urinary cyclic 3',5'-AMP after PTH and preceded the peak phosphaturic effect of PTH. There was no detectable effect of PTH on MI synthesis from glucose as a source of the MI released into the urine and perfusate. However, PTH temporarily halted accumulation of tritiated MI catabolites. There was no effect of inactivated PTH on urinary cyclic 3',5'-AMP or on MI transport, which indicates that the PTH effect on MI handling was a specific hormonal effect. These studies clarify the renal metabolism of MI, and they demonstrate heretofore unknown effects of PTH on the renal handling and metabolism of MI. The effects of PTH on renal MI metabolism have important implications in renal carbohydrate metabolism and phospholipid turnover.

show abstract

Section: Discussionmentioning

confidence: 99%

“…;lucose kidneys post-PTH injection there was a steadily increasing ad-100 min, which dition of 3H-metabolites to the perfusate. 10 Fig. 5.…”

Section: Methodsmentioning

confidence: 99%

Effects of Glucose and Parathyroid Hormone on the Renal Handling of Myoinositol by Isolated Perfused Dog Kidneys

Molitoris¹,

Hruska

Fishman

et al. 1979

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Stimulation of secretion is mediated by changes in cellular phospholipid and calcium metabolism (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). With concentrations of CCK and caerulein greater than -0.1 nM, secretion is progressively less than maximal (1).…”

Section: Introductionmentioning

confidence: 99%

Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell.

O’Konski

Pandol²

1990

J. Clin. Invest.

114

View full text Add to dashboard Cite

show abstract

“…In tissues such as pancreas, cerebral cortex, and parotid gland, stimulation by acetylcholinie elicits a breakdown of PI (3)(4)(5). The secretory response of platelets is essenitially complete within 30 s (6).…”

Section: Introductionmentioning

confidence: 99%

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979

View full text Add to dashboard Cite

Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas

Cited by 107 publications

References 9 publications

Effects of Glucose and Parathyroid Hormone on the Renal Handling of Myoinositol by Isolated Perfused Dog Kidneys

Effects of Glucose and Parathyroid Hormone on the Renal Handling of Myoinositol by Isolated Perfused Dog Kidneys

Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell.

Production of diglyceride from phosphatidylinositol in activated human platelets.

Contact Info

Product

Resources

About