Abstract:In the pathogenic bacterium Helicobacter pylori, post-transcriptional regulation is dominated by the activity of a protein complex, known as the RNA degradosome, composed of the essential ribonuclease RNase J and the DEAD-box RNA helicase RhpA. Here, we describe post-translational modifications of this protein complex that affect its activity. Cell-extracted RNase J is acetylated on multiple residues, one of which, K649, impacts strongly on RNase J oligomerization, which in turn influences recruitment into the… Show more
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