Acetylation of WCC is dispensable for the core circadian clock but differentially regulates acute light responses inNeurospora
Bin Wang,
Mark E. Edamo,
Xiaoying Zhou
et al.
Abstract:In theNeurosporacircadian system, the White Collar Complex (WCC) formed by WC-1 and WC-2 drives expression of thefrequency(frq) gene whose product FRQ feedbacks to inhibit transcriptional activity of WCC. Phosphorylation of WCC has been extensively studied, but the extent and significance of other post-translational modifications (PTM) has been poorly studied. To this end, we used mass-spectrometry to study alkylation sites on WCC, resulting in discovery of nine acetylation sites. Mutagenesis analysis showed m… Show more
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