Acetylation of acetaminophen in tablet formulations containing aspirin

Acylation of Phenol by Cyclic and Acyclic Anhydrides in Anhydrous Acetic Acid

“…The reactivity of energy-rich tetrahedral intermediates as well as cyclic and acyclic anhydrides will be discussed as models for high energy acylators, as postulated in numerous pharmaceutically important reactions. The pharmaceutical implications of transacylation reactions have been well documented (3)(4)(5)(6)(7)(8).…”

Degradation of vitamin D3 in a stressed formulation: The identification of esters of vitamin D3 formed by a transesterification with triglycerides

“…The solid-state acetylation of codeine phosphate [28,29], phenylephrine hydrochloride [30], acetaminophen [31] and homatropine [32] by aspirin have been reported. Codeine phosphate in the solid state has also been reported to be esterified by the acid component (citric or tartaric acid) in an effervescent tablet formulation [33].…”

Reactions of Acetaminophen in Pharmaceutical Dosage Forms: Its Proposed Acetylation by Acetylsalicylic Acid

“…Figure 3 shows a plot of the number of moles of free SA against the number of moles of DAPAP based on their data (4).…”