Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells
Jun‐Fei Zhang,
Zhi‐Ting Fang,
Jun‐Ning Zhao
et al.
Abstract:An increase in tau acetylation at K274 and K281 and abnormal mitochondrial dynamics have been observed in the brains of Alzheimer's disease (AD) patients. Here, we constructed three types of tau plasmids, TauKQ (acetylated tau mutant, by mutating its K274/K281 into glutamine to mimic disease‐associated lysine acetylation), TauKR (non‐acetylated tau mutant, by mutating its K274/K281 into arginine), and TauWT (wild‐type human full‐length tau). By transfecting these tau plasmids in HEK293 cells, we found that Tau… Show more
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