Acetoxy Group-Directed Regioselective C2 Alkenylation of Indoles via Pd–Ag Bimetallic Catalysis
Aditya Paul,
Arunava Sengupta,
Bijan Sarkar
et al.
Abstract:Regioselective C−H functionalizations of indoles reported to date with directing groups at C3 mainly rely on functional groups that are linked to the indole via C−C bonds. However, groups that are linked to the indole core by C−X linkages are also attractive due to the possibility of further modifications of the C−X bond. Herein, we report a 3-acetoxy directing group for the regioselective C2 alkenylation of indoles via a C−H activation-based, cross-dehydrogenative, oxidative Heck-type reaction. The reaction i… Show more
“…34,35 The integral equation formalism polarizable continuum model (IEFPCM) was applied in all the DFT calculations to approximate the solid environment, with the dielectric constant set to 4. [36][37][38][39][40][41] The vertical electron affinity (VEA) of PAGs was calculated using the following equation: 42 VEA = E(N) À E(N+1)…”
Photoacid generators (PAGs) are important components of chemically amplified resists. The properties of PAGs directly affect the sensitivity of photoresist, the line edge roughness, and resolution. Understanding the photoacid generation...
“…34,35 The integral equation formalism polarizable continuum model (IEFPCM) was applied in all the DFT calculations to approximate the solid environment, with the dielectric constant set to 4. [36][37][38][39][40][41] The vertical electron affinity (VEA) of PAGs was calculated using the following equation: 42 VEA = E(N) À E(N+1)…”
Photoacid generators (PAGs) are important components of chemically amplified resists. The properties of PAGs directly affect the sensitivity of photoresist, the line edge roughness, and resolution. Understanding the photoacid generation...
A new one-pot method for solvent-controlled switchable tandem oxidative triple functionalization of indolines has been developed via a successive regioselective chalcogenation, oxidation, amination and halogenation, in which iodine serve as...
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