Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds

Lima, Naiara Nascimento das Chagas; Faustino, Denise Carreiro; Allahdadi, Kyan James; França, Luciana Souza de Aragão; Pinto, Laíse Cedraz

doi:10.1016/j.phanu.2022.100295

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…Annonaceous acetogenins have attracted significant scientific interest for the last decade because of their biological activities such as antiparasitic, immunosuppressive, neurotoxic, and pesticidal properties [ 42 ]. Beyond that, these compounds appear to be powerful against cancer [ 6 , 42 , 43 ]. However, chronic exposure to annonaceous acetogenins can potentiate neural damage in the body; thus, moderate consumption of these compounds is recommended [ 43 ].…”

Section: Bioactive Compounds Found In Araticum Fruit Partsmentioning

confidence: 99%

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Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.

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Section: Bioactive Compounds Found In Araticum Fruit Partsmentioning

confidence: 99%

“…Beyond that, these compounds appear to be powerful against cancer [ 6 , 42 , 43 ]. However, chronic exposure to annonaceous acetogenins can potentiate neural damage in the body; thus, moderate consumption of these compounds is recommended [ 43 ].…”

Section: Bioactive Compounds Found In Araticum Fruit Partsmentioning

confidence: 99%

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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“…Despite their high selectivity for cancer cells, some acetogenins have neurotoxic potential, leading to neurodegenerative diseases such as Alzheimer’s and Parkinson’s ( Lannuzel et al, 2007 ; Chuzeville, 2015 ; Das and Nascimento, 2022 ). Acetogenins can promote the intracellular aggregation of a tau protein known as tauopathy, leading to the redistribution and accumulation of tau in somatodendrites ( Rottscholl, et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

In silico studies on cytotoxicity and antitumoral activity of acetogenins from Annona muricata L

Fallon Adido,

Silva Chagas,

Ferreira

et al. 2023

Front. Chem.

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As life expectancy increases, the number of people affected by cancer is increasing. The available drugs still cause several adverse reactions, and it is important to look for less toxic drugs that act on resistant cancers. The present study evaluated the antitumor potential of acetogenins. Through a literature review, 44 acetogenins isolated from Annona muricata were selected and subjected to in silico studies to predict the physicochemical properties, pharmacokinetics (Preadmet and Admet lab), toxicity (Preadmet and Protox II) and molecular docking in caspase 3 (DockThor). For muricatacin, a literature review was carried out for antitumor activity and cytotoxicity. Only muricatacin met all physicochemical criteria, while all compounds showed high cutaneous and intestinal absorption (HIA), moderate permeability in Madin-Darby canine kidney and Caco2 cells, strongly bound plasma proteins, freely crossed the blood-brain barrier, inhibited CYP2C19, CYP2C9 and CYP3A4 and have an affinity for CYP3A4, being metabolized by it, an undesirable characteristic for antitumor drugs. All compounds were toxic in at least one model, while compound 28 was not carcinogenic in rats and mice. Compounds 13, 14, 15, 16, 17 and 28 were selected for molecular docking into Caspase 3. Docking showed hydrophobic interactions, hydrogen and covalent bonds performed to maintain the stability of caspase 3, and cis-uvariamicin IV stood out more through the energies and chemical bonds of this parameter. The chloroform fraction from the methanolic extract of the seeds showed activity against triple-negative breast cancer, both in vitro and in vivo, and only muricatacin has studies in which the antitumor activity was evaluated in vitro and showed to be very promising. In summary, muricatacin and cis-uvariamicin IV appear to be very promising as antitumors, especially cis-uvariamicin IV.

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“…46 Acetogenins are more cytotoxic than alkaloids and rotenone, a synthetic cytotoxic chemical, according to certain research. 47 Due to their therapeutic potential against neurotoxic effects, acetogenins and alkaloids are intensively explored in a contentious form. Figure 2 shows the general skeleton of Annonaceous Acetogenin.…”

Section: Acetogeninsmentioning

confidence: 99%

Anticancer Properties of Graviola (Annona muricata Lin.): A Comprehensive Mechanistic Review

2024

TJNPR

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According to Ferlay, 6 WHO report, in 2008 alone, there were 12.7 million global new cancer cases; and it was suggested that it will increase to 17 million by 2021. This increase will be greater in low-and medium-resource countries. 7 Global cancer mortality is projected to rise continually, with over 18.1 million deaths in 2030. 8 Cancers, particularly breast cancer and prostate cancer, are now major health concerns in low-and middle-income countries (LMICs). 9 The WHO estimated that cancers will contribute to 84 million deaths between 2005 and 2015. 10 About 18.1 million new cases of cancers were expected to be diagnosed in 2018, with over 9.6 million deaths attributed to cancer globally. 11 It is pertinent to mention that 65-70% of these deaths were predicted to occur in LMIC. The most common cancer among the female population was cervix uteri (24.1%) followed by breast cancer (12.9%), and for the male population, it was prostate cancer (25.1%) and oesophhagus cancer (16.2%) according to the reports by National Cancer Institute. 12 Colon, esophageal, lung, nasopharyngeal, lymphoma, and prostate cancers are the five most prevalent cancers in men, whereas liver, colorectum, lung, breast, ovary and cervix uteri cancers are the most common malignancies in women. 13 At least 80% of cancer patients will require surgery as part of their treatment. 14 The Lancet Oncology Commission proposes prioritizing cancers with a high disease burden and in which surgery plays a critical role. 14 Despite major advances in the fields of surgery, chemotherapy, and radiotherapy, many people still have reservations about these treatments because of their limitations and, most importantly, their side effects. Although conventional 3D radiation therapy has been demonstrated to be beneficial in the treatment of head and neck cancers, the side effects typically cause discomfort and a decrease in patients' quality of life. Xerostomia, which causes weight loss, and persistent infections in the oral cavity and dental cavities are examples of side effects. 15 Although the invention of intensity-modulated radiotherapy (IMRT) to replace conventional radiation therapy allows for the preservation of the parotid glands and an overall improvement in patient quality of life, large doses of IMRT radiation have been linked to dysphagia in patients. 16

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Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds

Cited by 9 publications

References 32 publications

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

In silico studies on cytotoxicity and antitumoral activity of acetogenins from Annona muricata L

Anticancer Properties of Graviola (Annona muricata Lin.): A Comprehensive Mechanistic Review

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