Acetogenins and Other Compounds from Rollinia emarginata and Their Antiprotozoal Activities

Février, Anne; Ferreira, Marı́a Elena; Fournet, Alain; Yaluff, Gloria; Inchausti, Alba; Árias, Antonieta Rojas de; Hocquemiller, Reynald; Waechter, Anne-Isabelle

doi:10.1055/s-1999-13961

Cited by 37 publications

(16 citation statements)

References 2 publications

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“…However, some Rollinia species are used in traditional medicine for tumour treatment (Zeng et al, 1996). Prior studies have shown that crude extracts from Rollinia species display in vitro activities against Leishmania braziliensis, Leishmania amazonensis and Leishmania donovani promastigotes and Trypanosoma cruzi trypomastigotes (Février et al, 1999). Antimicrobial and antifungal activities have also been described (Caetano and Dadoun, 1987).…”

Section: Discussionmentioning

confidence: 99%

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Osorio

Arango

Jimenez

et al. 2007

Journal of Ethnopharmacology

141

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Section: Discussionmentioning

confidence: 99%

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Osorio

Arango

Jimenez

et al. 2007

Journal of Ethnopharmacology

141

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“…Against different Leishmania and T. cruzi strains at 250 µg/mL inhibitory activity up to 89% and 67% was reported for rolliniastatin-1 (3) and squamocin (4) [35]. The leishmanicical activity was related to the number of hydroxy groups on these acetogenins.…”

Section: Organic Acids Lipids and Acetogeninsmentioning

confidence: 99%

“…The secoiridoid amarogentin (35) isolated from the upper parts of Swertia chirata (Loganiaceae) is a promising compound with leishmanicidal activity. This compound inhibited DNA-Topoisomerase I activity from Leishmania donovani at 30 µM [79].…”

Section: Iridoidsmentioning

confidence: 99%

Natural products as potential antiparasitic drugs

Kayser

Kiderlen

Croft

2002

Studies in Natural Products Chemistry

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Pharmaceutical research in natural products represents a major strategy for discovering and developing new drugs. The use of medicinal plants for the treatment of parasitic diseases is well known and documented since ancient times e.g. by the use of Cinchona succiruba (Rubiaceae) as an antimalarial. This chapter provides a comprehensive review of the latest results in the field of antiparasitic drug development from biologic sources (plants, bacteria, fungi and marine organisms) focussing on the treatment of protozoal infections (Plasmodium, Leishmania, Trypanosoma spp.). The status of validated in vitro and in vivo assays is reviewed, discussing their different features, problems and limitations. Because of the high number of natural products tested against the aforesaid protozoa in the last years, we limit the discussion to lignans, phenolics, terpenoids, and alkaloids as defined natural product classes. The review also covers essential research topics of recent publications on specific natural products (e.g. licochalcone A, benzyl-and naphthylisoquinoline alkaloids, and artemisinin) and gives an outlook to semisynthetic approaches of drugs already introduced in clinics or in clinical trial studies.

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“…The oxoaporphine alkaloid liriodenine (142) and the zwitterionic derivative N-methylliriodendronine (143) isolated from the African medicinal shrub Stephania dinklagei (Menispermaceae) exhibited activity against L. donovani promastigotes (IC 50 values of 15 and 19 µM , respectively). However, these alkaloids were less active against L. donovani amastigotes, and 142 displayed an IC 50 of 27 µg/mL against KB cells [114].…”

Section: Other Alkaloidsmentioning

confidence: 99%

Natural Products from Plants as Drug Candidates and Lead Compounds Against Leishmaniasis and Trypanosomiasis

Salem

Werbovetz²

2006

CMC

131

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Millions of people in the developing world are affected by diseases caused by the kinetoplastid parasites: the leishmaniases, African trypanosomiasis, and Chagas disease. In many cases the drugs employed for treatment are toxic, marginally effective, given by injection, and/or compromised by the development of resistance. Since safe, effective, and affordable chemotherapeutic agents for leishmaniasis and trypanosomiasis are clearly needed, the identification of new antikinetoplastid drug candidates should be an urgent priority. Numerous plant-derived natural products from different structural classes have been investigated as antileishmanial and antitrypanosomal candidates, including various alkaloids, terpenoids, flavonoids, and quinonoids. This review outlines the antikinetoplastid activities of plant-derived natural products reported in the literature and also provides an overview of mechanistic studies that have been conducted with these compounds. Given the activities of these agents and their diverse range of effects on parasite biology, natural products are a potentially rich source of drug candidates and leads against leishmaniasis and trypanosomiasis.

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Acetogenins and Other Compounds from Rollinia emarginata and Their Antiprotozoal Activities

Cited by 37 publications

References 2 publications

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Natural products as potential antiparasitic drugs

Natural Products from Plants as Drug Candidates and Lead Compounds Against Leishmaniasis and Trypanosomiasis

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