Acetogen and acetogenesis for biological syngas valorization

Kim, Jiyeon; Lee, Mungyu; Oh, So-Young; Kang, Byeongchan; Yasin, Muhammad; Chang, In Seop

doi:10.1016/j.biortech.2023.129368

Cited by 5 publications

(2 citation statements)

References 131 publications

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“…In this regard, EG is a promising next-generation feedstock that can be derived from materials not competing food stocks, and EG preparation by means of sustainable process is rapidly developing. Thus, research on microbial conversion of EG to value-added chemicals will contribute to the development of a sustainable industry in parallel with research on microbial conversion of other potential next-generation feedstocks such as syngas (Kim et al 2023 ), CO 2 (Nisar et al 2021 ), methanol (Zhang et al 2019 ), and acetate (Kiefer et al 2021 ).…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Novel aspects of ethylene glycol catabolism

Shimizu,

Inui

2024

Appl Microbiol Biotechnol

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Ethylene glycol (EG) is an industrially important two-carbon diol used as a solvent, antifreeze agent, and building block of polymers such as poly(ethylene terephthalate) (PET). Recently, the use of EG as a starting material for the production of bio-fuels or bio-chemicals is gaining attention as a sustainable process since EG can be derived from materials not competing with human food stocks including CO2, syngas, lignocellulolytic biomass, and PET waste. In order to design and construct microbial process for the conversion of EG to value-added chemicals, microbes capable of catabolizing EG such as Escherichia coli, Pseudomonas putida, Rhodococcus jostii, Ideonella sakaiensis, Paracoccus denitrificans, and Acetobacterium woodii are candidates of chassis for the construction of synthetic pathways. In this mini-review, we describe EG catabolic pathways and catabolic enzymes in these microbes, and further review recent advances in microbial conversion of EG to value-added chemicals by means of metabolic engineering. Key points • Ethylene glycol is a potential next-generation feedstock for sustainable industry. • Microbial conversion of ethylene glycol to value-added chemicals is gaining attention. • Ethylene glycol-utilizing microbes are useful as chassis for synthetic pathways.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Novel aspects of ethylene glycol catabolism

Shimizu,

Inui

2024

Appl Microbiol Biotechnol

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“…Acetyl-CoA serves as a precursor for biomass synthesis or for the generation of specific products, such as acetate and ethanol. So far, over 100 acetogenic species in 23 genera have been identified that grow under a wide range of temperature and pH ( Drake et al, 2006 ; Lee et al, 2022 ) Depending on the species, in addition to acetate, diverse biochemicals, including ethanol, 2,3-butanediol, lactate, or other acids and alcohols can be produced from C1 feedstocks ( Kim et al, 2023 ). However, not all the acetogens have been investigated in details.…”

Section: Introductionmentioning

confidence: 99%

Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals

Zhang,

Li,

et al. 2024

Front. Bioeng. Biotechnol.

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Acetogenic bacteria (acetogens) are a class of microorganisms with conserved Wood-Ljungdahl pathway that can utilize CO and CO2/H2 as carbon source for autotrophic growth and convert these substrates to acetate and ethanol. Acetogens have great potential for the sustainable production of biofuels and bulk biochemicals using C1 gases (CO and CO2) from industrial syngas and waste gases, which play an important role in achieving carbon neutrality. In recent years, with the development and improvement of gene editing methods, the metabolic engineering of acetogens is making rapid progress. With introduction of heterogeneous metabolic pathways, acetogens can improve the production capacity of native products or obtain the ability to synthesize non-native products. This paper reviews the recent application of metabolic engineering in acetogens. In addition, the challenges of metabolic engineering in acetogens are indicated, and strategies to address these challenges are also discussed.

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