Acetic anhydride as a synthetic reagent

Kim, Donghan

doi:10.1002/jhet.5570130201

Cited by 15 publications

(2 citation statements)

References 103 publications

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“…Besides using of classical acids and bases, several Lewis acid catalysts, solid acid and heteropolyacid catalysts, organocatalysts, ionic liquids and others have been used for the acylation reactions [21]. Amides are commonly produced by N-acylation of amines [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Powder-Catalyzed, Highly Efficient, Solvent-Free Synthesis of Amides through N-Acetylation of Amines and their Antibacterial Activity

Bajracharya,

Shrestha,

Bajracharya

2024

ajc

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Magnesium powder was found to be an efficient catalyst for the acetylation of amines (1) with Ac2O affording corresponding amides (2) in excellent yields (> 99%). This green synthetic protocol has utilized 2.5 mol% of magnesium powder and a stoichiometric amount of Ac2O (1.2 equiv.). Amides 2a-k were synthesized within a short reaction time (2-3 min) at an ambient temperature under solvent free condition. The products were screened against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis bacterial strains. N-(2-Hydroxyphenyl)acetamide (2f) was found most active against Gram-positive S. aureus and S. epidermidis indicating its efficacy in treating skin diseases.

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Section: Introductionmentioning

confidence: 99%

Magnesium Powder-Catalyzed, Highly Efficient, Solvent-Free Synthesis of Amides through N-Acetylation of Amines and their Antibacterial Activity

Bajracharya,

Shrestha,

Bajracharya

2024

ajc

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“…N-acetylation is a widely used chemical reaction in general organic chemistry to build an acetyl functional group on an amine compound [1][2][3][4]. The use of the acetyl functional group is widespread, including drug research, the preparation of pharmaceuticals, polymer chemistry and agrochemical applications [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives

2020

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A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.

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