Acetic acid-promoted condensation of o-phenylenediamine with aldehydes into 2-aryl-1-(arylmethyl)-1H-benzimidazoles under microwave irradiation

Abstract

An efficient and simple procedure was developed for the green synthesis of various 2-aryl-1-(arylmethyl)-1H-benzimidazoles in high yields by acetic acid-promoted condensation of o-phenylenediamine with aldehydes in air under microwave irradiation and transition metal catalyst-free conditions.

Aromatization of 1,3,5-Trisubstituted of 4,5-Dihydro-1H-Pyrazoles by In-Situ Generation of I+from Hydrogen Peroxide/Acids/Iodide Potassium or Sodium Systems

“…[37][38][39] However, we preferred hydrogen peroxide as oxidant over other available oxidizing agents since it is cheap, operationally safe, environmentally friendly, easy to handle and produces only water as a by product, which reduces purification requirements. [40][41][42][43] The HI is highly toxic and corrosive as harmful as molecular iodine to the environment.…”

KIT‐6 Mesoporous Silica‐coated Magnetite Nanoparticles: A Highly Efficient and Easily Reusable Catalyst for the Synthesis of Benzo[d]imidazole Derivatives

“…All of the synthesized compounds were characterized by their physical constant, comparison with authentic samples, IR, 1 H NMR, 13 C NMR spectroscopy, and elemental analysis. All of synthesized compounds are known as described by [34]. 13…”

Green Synthesis of Benzimidazole Derivatives: an Overview on Green Chemistry and Its Applications

“…They concluded that a gentle manipulated method, eco-friendly and green aspects avoiding hazardous solvents, shorter reaction times and high yields of the products are the advantages of this method [35]. condition via oxidation of carbon-nitrogen bond which is a green, mild and inexpensive method [36]. acid/HCl confirming the use of a simple condensation method and ring-closing agents for the synthesis of 2-substituted benzimidazoles [37].…”